Understanding the differentiation of the endocardium

了解心内膜的分化

• 批准号: DP170101217
• 负责人: A/Prof Kelly Smith
• 金额: $ 29.97万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP170101217
• 关键词: Understanding; differentiation; endocardium

The project aims to understand the genetic regulation of endocardial development. The heart is essential for survival, its beat the indicator of life. The endocardium, the heart’s inner lining, is required for signalling during heart development and is a major component of the valves, septa and trabeculae. Despite its indispensable role, little is known about how it forms or develops. This project integrates two complementary approaches that have identified the earliest marker of endocardial differentiation and devised the method to make endocardium from stem cells. Knowledge from this work will inform future research into growing and regenerating damaged tissue.

该项目旨在了解心内膜发育的遗传调控。心脏是生存所必需的，它的跳动是生命的指示器。心内膜是心脏发育过程中信号传递所必需的，是瓣膜、间隔和小梁的主要组成部分。尽管它扮演着不可或缺的角色，但人们对它的形成和发展知之甚少。该项目整合了两种互补的方法，确定了心内膜分化的最早标记，并设计了从干细胞制造心内膜的方法。从这项工作中获得的知识将为未来对受损组织生长和再生的研究提供信息。