High resolution phylogenetic analysis of livestock-associated Staphylococcus aureus.

家畜相关金黄色葡萄球菌的高分辨率系统发育分析。

• 批准号: BB/I013873/1
• 负责人: Ross Fitzgerald
• 金额: $ 42.85万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FI013873%2F1
• 关键词: resolution; phylogenetic; analysis; livestock; associated

An understanding of the basis for the emergence of endemic diseases of livestock is critical for designing new approaches for their control and to prevent new pathogens from emerging. In particular, the role of human activities such as industrialization and globalization in the evolution of pathogens has not been well examined to date. Staphylococcus aureus is notorious as a major human pathogen and is also an important pathogen of farmed animals including cows, sheep, goats, poultry and pigs, resulting in huge economic losses. Recent studies have provided evidence that S. aureus strains affecting livestock have evolved from human strains and have undergone genetic adaptation to cause endemic diseases of animals. Furthermore, some livestock-associated strains have the capacity to cause zoonotic infections of humans. In the current project we will use high throughput sequencing technology to achieve a comprehensive genetic analysis of livestock-associated S. aureus. The project will reveal the evolutionary origin of livestock-associated S. aureus, how they have adapted to animal hosts, and their potential to cause human infections. The genetic analyses will also facilitate the identification of targets for developing new approaches to controlling endemic livestock disease. Overall, the project will contribute important new insights into a critical animal welfare, food security and public health issue.

了解牲畜地方病出现的基础对于设计新的防治办法和防止新病原体的出现至关重要。特别是，迄今为止，还没有很好地研究工业化和全球化等人类活动在病原体演变中的作用。金黄色葡萄球菌（Staphylococcus aureus）是人类的主要病原菌，也是奶牛、绵羊、山羊、家禽和猪等养殖动物的重要病原菌，给人类造成了巨大的经济损失。最近的研究提供了证据，S。影响牲畜的金黄色葡萄球菌菌株是从人类菌株进化而来的，并经历了遗传适应，导致动物的地方病。此外，一些与牲畜有关的菌株有能力引起人类的人畜共患病感染。本项目将利用高通量测序技术对畜禽相关沙门氏菌进行全面的遗传分析。金黄色。该项目将揭示与家畜相关的S.金黄色葡萄球菌，它们如何适应动物宿主，以及它们引起人类感染的潜力。遗传分析还将有助于确定目标，以制定控制地方性牲畜疾病的新办法。总体而言，该项目将为关键的动物福利，食品安全和公共卫生问题提供重要的新见解。

项目成果

A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.

• DOI: 10.1101/gr.147710.112
• 发表时间: 2013-04
• 期刊: Genome research
• 影响因子: 7
• 作者: Holden MT;Hsu LY;Kurt K;Weinert LA;Mather AE;Harris SR;Strommenger B;Layer F;Witte W;de Lencastre H;Skov R;Westh H;Zemlicková H;Coombs G;Kearns AM;Hill RL;Edgeworth J;Gould I;Gant V;Cooke J;Edwards GF;McAdam PR;Templeton KE;McCann A;Zhou Z;Castillo-Ramírez S;Feil EJ;Hudson LO;Enright MC;Balloux F;Aanensen DM;Spratt BG;Fitzgerald JR;Parkhill J;Achtman M;Bentley SD;Nübel U
• 通讯作者: Nübel U

Phylogenetic analysis of Staphylococcus aureus CC398 reveals a sub-lineage epidemiologically associated with infections in horses.

• DOI: 10.1371/journal.pone.0088083
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Abdelbary MM;Wittenberg A;Cuny C;Layer F;Kurt K;Wieler LH;Walther B;Skov R;Larsen J;Hasman H;Fitzgerald JR;Smith TC;Wagenaar JA;Pantosti A;Hallin M;Struelens MJ;Edwards G;Böse R;Nübel U;Witte W
• 通讯作者: Witte W

Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.

LUKPQ的鉴定，这是金黄色葡萄球菌的新型，均等的白细胞素。

• DOI: 10.1038/srep40660
• 发表时间: 2017-01-20
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Koop G;Vrieling M;Storisteanu DM;Lok LS;Monie T;van Wigcheren G;Raisen C;Ba X;Gleadall N;Hadjirin N;Timmerman AJ;Wagenaar JA;Klunder HM;Fitzgerald JR;Zadoks R;Paterson GK;Torres C;Waller AS;Loeffler A;Loncaric I;Hoet AE;Bergström K;De Martino L;Pomba C;de Lencastre H;Ben Slama K;Gharsa H;Richardson EJ;Chilvers ER;de Haas C;van Kessel K;van Strijp JA;Harrison EM;Holmes MA
• 通讯作者: Holmes MA

Not just a matter of size: a hospital-level risk factor analysis of MRSA bacteraemia in Scotland.

• DOI: 10.1186/s12879-016-1563-6
• 发表时间: 2016-05-21
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Gibbons CL;van Bunnik BAD;Blatchford O;Robertson C;Porphyre T;Imrie L;Wilson J;Fitzgerald JR;Woolhouse MEJ;Chase-Topping ME
• 通讯作者: Chase-Topping ME