ENTERIC DISEASES IN A POPULATION AT RISK FOR AIDS

艾滋病高危人群中的肠道疾病

• 批准号: 3131699
• 负责人: JOHN G BARTLETT
• 金额: $ 23.17万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-06-01 至 1987-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3131699
• 关键词: AIDS; Adenoviridae; Alphaherpesvirinae; Betaherpesvirinae; Candida albicans; Chlamydia trachomatis; Chlamydiaceae; Clostridium; Coccidia; Coxsackievirus; Cryptosporidium; Entamoeba histolytica; Giardia; Neisseria gonorrhoeae; Rotavirus; Salmonella; Shigella; Treponema; Vibrio; Yersinia pestis disease; acute infectious nonbacterial gastroenteritis; biopsy; contrast media; delayed hypersensitivity; disease /disorder proneness /risk; endoscopy; enteric bacteria; enteritis; enzyme linked immunosorbent assay; epidemiology; gastroenteritis; gastrointestinal imaging /visualization; homosexuals; human subject; immunologic skin test; longitudinal human study; male; microorganism immunology; parasitic disease diagnosis; serotyping; tissue /cell culture

Prior studies suggest that intestinal disease, primarily proctitis and proctocolitis, is a frequent problem in homosexual men. A variety of pathogens have been implicated including commonly-recognized transmissible agents of enteric disease as well as multiple organisms recognized as agents of sexually transmitted diseases. More recent work also indicates that diarrhea and opportunistic infection are common features of AIDS and the AIDS-related complex. The purpose of our study will be to examine enteric pathogens and enteric disease in homosexual men, a group at risk for AIDS. The source of participants will be another study entitled "Natural History of AIDS in Homosexual Men". This parent study involves a cohort of 1,000 homosexual men from the Greater Baltimore area who are followed a six month intervals for three years with the major goal of identifying variables associated with altered immune status and the risk of developing immune defects including AIDS. Our studies will include analyses of rectal swabs or stools to detect 20 infectious agents including N. gonorrhoeae, T. pallidum, C. trachomatis (including LGV strains), H. simplex, CMV, Giardia, E. histolytica, Cryptosporidium, Isospora, Salmonella, Shigella, Campylobacter, Aeromonas, C. difficile, Yersinia, Vibrio, rotavirus, adenovirus, Coxsackie viruses and C. albicans. There will be three studies: 1) a prevalence study involving cross-sectional analysis from a randomly selected population of 200 patients; 2) a case-control study to define the incidence, clinical characteristics and agents of symptomatic disease among the 1,000 participants followed prospectively for 3 years; 3) an epidemiologic study designed to detect carriage of pathogens in sexual contacts of patients with symptomatic disease; and 4) an intensive evaluation of intestinal disease in participants and patients that develop AIDS for AIDS-related complex. A unique aspect of this work is that extensive data will be obtained in the parent study to define behavioral practices and to define immune function of participants. This information, which does not require separate funding, will be included in data analysis of the present study to identify risk factors associated with intestinal carriage or symptomatic disease and to examine possible relationships between enteric infections and alterations in the immune system.

先前的研究表明，肠道疾病，主要是肠炎和 凝血结肠炎是同性恋男性的常见问题。 各种各样 病原体已被暗示，包括普遍认可的传播 肠道疾病的药物以及多种被公认为的生物 性传播疾病的药物。 最近的工作也表明 腹泻和机会性感染是艾滋病的常见特征， 与艾滋病相关的复合物。 我们研究的目的是检查 同性恋男性的肠道病原体和肠道疾病，这是一个有风险的群体 艾滋病。 参与者的来源将是另一项题为的研究 “同性恋男人的艾滋病的自然历史”。 这项父母研究涉及 来自大巴尔的摩地区的1,000名同性恋者的队列 紧随六个月的间隔三年，主要目标是 识别与免疫状态改变有关的变量和 开发包括艾滋病在内的免疫缺陷。 我们的研究将包括对直肠拭子或凳子的分析，以检测20 传染剂，包括N. gonorrhoeae，T。Pallidum，C。trachomatis （包括LGV菌株），H。纯曲，CMV，贾第二体，E。histolictica， 隐孢子虫，等孢子，沙门氏菌，志贺氏菌，弯曲杆菌，气动作， 艰难梭菌，耶尔森氏菌，弧菌，轮状病毒，腺病毒，coxsackie病毒 和白色念珠菌。 将有三项研究：1）一项患病率研究 涉及随机选择的人群的横截面分析 200名患者； 2）一项病例对照研究，以定义发病率 1,000的症状疾病的特征和药物 参与者预期遵循了3年； 3）流行病学研究 旨在检测患者性接触中病原体的运输 有症状疾病； 4）对肠道的深入评估 参与者和患者开发艾滋病相关的艾滋病的疾病 复杂的。 这项工作的一个独特方面是，大量数据将是 在父母的研究中获得以定义行为实践并定义 参与者的免疫功能。 此信息，不需要 单独的资金将包括在本研究的数据分析中 确定与肠运输或有症状相关的危险因素 疾病并检查肠道感染之间可能的关系 和免疫系统的改变。

项目成果

Recovery of Campylobacter species from homosexual men.

从同性恋男性中回收弯曲杆菌属。

• DOI: 10.1093/infdis/158.2.464
• 发表时间: 1988
• 期刊: The Journal of infectious diseases
• 作者: Laughon,BE;Vernon,AA;Druckman,DA;Fox,R;Quinn,TC;Polk,BF;Bartlett,JG
• 通讯作者: Bartlett,JG

Prevalence of enteric pathogens in homosexual men with and without acquired immunodeficiency syndrome.

患有和不患有获得性免疫缺陷综合症的同性恋男性肠道病原体的患病率。

• DOI: 10.1016/0016-5085(88)90557-4
• 发表时间: 1988
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Laughon,BE;Druckman,DA;Vernon,A;Quinn,TC;Polk,BF;Modlin,JF;Yolken,RH;Bartlett,JG
• 通讯作者: Bartlett,JG