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mRNA-specific translational control: A novel mechanism.

mRNA 特异性翻译控制：一种新机制。

基本信息

批准号：
BB/I02137X/1
负责人：
Nicola Gray
金额：
$ 29.98万
依托单位：
University of Edinburgh
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2011
资助国家：
英国
起止时间：
2011 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FI02137X%2F1
关键词：
mRNA specific translational control novel

项目摘要

The proteins that make up our cells are encoded by genes that serve as a genetic blueprint. The information stored in genes is decoded to produce proteins by a two-step process, the second of which is known as translation. Since it is crucial that proteins are made at the right time and in the right amount for the cell to function properly, it is important that translation is carefully regulated. Indeed, a failure to do so has been shown to underlie a growing number of diseases. The ability to regulate translation is also crucial for cells to respond to viral infection. In turn, viruses rely entirely on the cells they infect to produce the viral proteins necessary for infection to proceed and have therefore developed ways in which to subvert normal cellular protein production to suit their own needs. Thus the study of host-virus interactions has provided much of our current understanding of the basic translational machinery and its regulation. By studying the mechanism of a herpes simplex virus protein, as an example of a novel regulator of translation, we aim to increase our knowledge of how cells normally control this process. Understanding normal cellular function is critical to elucidating the pathways that lead to disease. Moreover, as even distantly related members of this large viral family have similar proteins that are essential to their ability to infect cells, knowledge of the action of this protein may also be beneficial in developing new ways to combat a broad range of herpesviruses that cause a wide variety of diseases both in humans and animals.

构成我们细胞的蛋白质是由基因编码的，这些基因是遗传蓝图。储存在基因中的信息通过两个步骤解码产生蛋白质，第二个步骤称为翻译。由于蛋白质在正确的时间和正确的数量产生对于细胞正常运作至关重要，因此仔细调节翻译非常重要。事实上，不这样做已被证明是越来越多疾病的根源。调节翻译的能力对于细胞对病毒感染的反应也至关重要。反过来，病毒完全依赖于它们感染的细胞来产生感染所必需的病毒蛋白，因此开发了破坏正常细胞蛋白生产的方法来满足自己的需要。因此，宿主-病毒相互作用的研究为我们提供了目前对基本翻译机制及其调控的理解。通过研究单纯疱疹病毒蛋白的机制，作为一种新型翻译调节剂的例子，我们的目标是增加我们对细胞如何正常控制这一过程的了解。了解正常的细胞功能对于阐明导致疾病的途径至关重要。此外，由于即使是这个大型病毒家族的远亲成员也具有对其感染细胞的能力至关重要的相似蛋白质，因此了解这种蛋白质的作用也可能有助于开发新的方法来对抗在人类和动物中引起各种疾病的各种疱疹病毒。