ARTICULAR CARTILAGE HEALING AND PASSIVE MOTION

关节软骨疾病使更多的人比其他任何群体残疾 肌肉骨骼问题。 任何改善修复的治疗 关节软骨的价值将是无价的 报告称，持续被动 运动（CPM）促进1 mm直径全层缺损的愈合， 兔关节软骨刺激使用CPM促进 人体软骨形成 然而，CPM在治疗 与人类临床问题非常相似的缺陷还没有被 我们的初步研究表明， 粉末冶金修复灵长类动物关节3种直径4 mm缺损的实验研究 软骨 本次调查的目的是：1）核实以前的报告，CPM 促进软骨愈合;并确定：2）缺损大小是否影响 CPM治疗的关节软骨愈合; 3）如果愈合 CPM（每天24小时PM）诱导的愈合与诱导的愈合不同， 间歇性被动运动，IPM，（每天16小时PM）;以及4）如果 用PM或铸件治疗的关节缺损的愈合是相同的， 膝关节更接近人类的兔子和食蟹猴 膝盖 为了证实以前的报告，评估缺陷尺寸的重要性， 比较CPM和IPM，直径为1 mm和3.2 mm的全厚度缺损将 在兔负重股骨关节面中制备并处理 使用CPM、IPM或铸造。 为了评估PM在关节中的作用， 更接近人类膝盖，直径为1 mm和3.2 mm的钻头 将在灵长类动物的关节面中制造孔状缺损并进行治疗 并与家兔的结果进行比较 实验 腕关节修复将由一个新的 软骨修复的形态学-组织化学指标的可靠性测试 并基于软骨损伤和修复中的事件顺序。 的 指数的有效性将通过比较指数值与 修复软骨的生化成分。 从这项研究中获得的信息将加强我们对 PM在关节缺损愈合中的作用， 人类临床上显著的缺陷。 如果这项研究表明， 促进关节软骨愈合，将提出建议， 研究PM在其他类型的关节软骨缺损中的作用， 骨关节炎动物模型的建立，并探讨其基本机制。 PM对软骨形成的影响。

Disorders of articular cartilage disable more people than any other group of musculoskeletal problems. Any treatment that improves repair of articular cartilage would be invaluable. Reports that continuous passive motion (CPM) promotes healing of 1 mm diameter full thickness defects in rabbit articular cartilage have stimulated use of CPM to promote chondrogenesis in humans. However, the value of CPM in treatment of defects that closely resemble clinical problems in humans has not been demonstrated and our preliminary studies did not show a positive effect of PM in healing three types of 4 mm diameter defects in primate articular cartilage. The aims of this investigation are to: 1) verify previous reports that CPM facilitates cartilage healing; and to determine: 2) if defect size affects the healing of articular cartilage treated with CPM; 3) if the healing induced by CPM (24 hours of PM per day) differs from the healing induced intermittent passive motion, IPM, (16 hours of PM per day); and 4) if healing of articular defects treated with PM or casting is the same in rabbits and cynomolgus monkeys whose knees more closely resemble human knees. To confirm previous reports, assess the importance of defect size, and compare CPM and IPM, 1 mm and 3.2 mm diameter full thickness defects will be made in rabbit weight bearing femoral articular surfaces and treated with CPM, IPM or casting. To evaluate the effects of PM in joints that more closely resemble human knees, 1 mm diameter and 3.2 mm diameter drill hole defects will be made in the articular surfaces of primates and treated with cast immobilization or IPM and compared with the results of the rabbit experiments. Cartilage repair will be evaluated by a new morphologic-histochemical index of cartilage repair tested for reliability and based on the sequence of events in cartilage injury and repair. The validity of the index will be assessed by comparing the index values with the biochemical composition of the repair cartilage. Information gained from this study will enhance our understanding of the role of PM in the healing of articular defects that more closely resemble clinically significant defects in humans. If this study shows that PM facilitates articular cartilage healing, proposals will be developed to study the effect of PM in other types of articular cartilage defects and in animal models of osteoarthritis and to explore the basic mechanism of the PM effect on chondrogenesis.