课题基金 / 基金详情

COMPLEMENT BIOSYNTHESIS

COMPLEMENT BIOSYNTHESIS
补体生物合成
批准号：
3138046
负责人：
HARVEY R COLTEN
金额：
$22.02万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
项目状态：
已结题
起止时间：
1986-06-01 至 1988-11-30
来源：
https://reporter.nih.gov/project-details/3138046
关键词：
Xenopus autoradiography bone marrow cell differentiation cell free system complement complement deficiency complement inhibitors complement pathway enzyme mechanism enzyme structure flow cytometry gene expression genetic strain genetic translation guinea pigs human milk human tissue immunochemistry macrophage messenger RNA monocyte nucleic acid probes phagocytes protein biosynthesis radiotracer secretory immune system

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中文摘要
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英文摘要
The purpose of the proposed studies is to define molecular and cellular controls that govern the biosynthesis and secretion of complement proteins. Cell free biosynthetic studies will be conducted, structural analysis of primary translation products and elucidation of the post synthetic modifications will be accomplished with samples generated in vivo and established cell lines and primary human and experimental animal cell cultures. Cellular regulatory mechanisms will be investigated in studies of mononuclear phagocyte maturation and in isolated macrophage subpopulations. The availability of a cDNA probe for the MHC class III genes factor B and C4 will permit analysis of the transcription and post-transcriptional modifications relevant to normal gene expression and by extension to analysis of the genetic deficiencies of complement in two guinea pig strains.
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MOLECULAR REGULATION OF MHC CLASS III GENES
  • 批准号：
    6108385
  • 项目类别：
  • 资助金额：
    $22.15万
  • 财政年份：
    1998
  • 负责人：
    HARVEY R COLTEN
  • 依托单位：
    IMMUNE DISEASE INSTITUTE, INC.
MOLECULAR REGULATION OF MHC CLASS III GENES
  • 批准号：
    6240937
  • 项目类别：
  • 资助金额：
    $21.39万
  • 财政年份：
    1997
  • 负责人：
    HARVEY R COLTEN
  • 依托单位：
    IMMUNE DISEASE INSTITUTE, INC.
MOLECULAR GENETICS OF THE MHC LINKED COMPLEMENT GENES
  • 批准号：
    2062710
  • 项目类别：
  • 资助金额：
    $21.41万
  • 财政年份：
    1987
  • 负责人：
    HARVEY R COLTEN
  • 依托单位：
    WASHINGTON UNIVERSITY
MOLECULAR GENETICS OF THE MHC LINKED COMPLEMENT GENES
  • 批准号：
    3481304
  • 项目类别：
  • 资助金额：
    $20.72万
  • 财政年份：
    1987
  • 负责人：
    HARVEY R COLTEN
  • 依托单位：
    WASHINGTON UNIVERSITY
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