SPECIFICITY DISTRIBUTION & FUNCTION OF GAMMA DELTA T CEL
SPECIFICITY DISTRIBUTION & FUNCTION OF GAMMA DELTA T CEL
批准号:
3142141
负责人:
ROBERT E. TIGELAAR
金额:
$21.16万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1989
资助国家:
美国
项目状态:
已结题
起止时间:
1989-04-01 至 1996-03-31
关键词:
CD8 molecule MHC class I antigen T cell receptor T lymphocyte antigen presentation cellular immunity gastrointestinal epithelium gene expression gut associated lymphoid tissue hybridomas interferons interleukin 2 interleukin 4 laboratory mouse leukocyte activation /transformation microorganism immunology polymerase chain reaction protozoa protozoal infection
中文摘要
在数量上,伽马三角洲T细胞是
广泛分化的脊椎动物的免疫系统,包括人类。他们的
然而,人体内的功能仍然未知。我们在1988年提出
它们在很大程度上负责保护表面上皮细胞。
抵抗原发感染,推理他们可能认识到“压力”
抗原。虽然许多数据支持这一评估,但仍有非常多的
很少有数据表明当动物上皮细胞
系统性感染。本研究以伽马三角洲为研究对象。
T细胞感染整个脊椎动物门动物的原生动物。
这些实验将得到其他鉴定蛋白质的人的支持。
在其他被伽马增量T细胞识别的细胞上。加在一起,这些
实验将帮助我们了解这组新发现的
淋巴细胞有助于保护动物免受疾病侵袭。
英文摘要
In numbers, gamma delta T cells represent a significant component of the
immune system in widely diverged vertebrates, including humans. Their
function in the body remains, however, unknown. We proposed in 1988 that
they were in large part responsible for the protection of surface epithelia
against primary infection, reasoning that they may recognize 'stress'
antigens. While much data supports this assessment, there is still very
little data concerning what happens when animal epithelia are
systematically infected. This study focuses on the response of gamma delta
T cells to protozoans that infect animals across the vertebrate phylum.
The experiments will be supported by others that will identify the proteins
on other cells that are recognized by gamma delta T cells. Together, these
experiments will help us understand how this newly-discovered set of
lymphocytes helps protect animals from disease.
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专著(0)
科研奖励(0)
会议论文
Genome Wide Analysis of Melanocytic Lesions
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批准号:7508860
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项目类别:
-
资助金额:$3.97万
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财政年份:2007
-
负责人:ROBERT E. TIGELAAR
-
依托单位:
Administrative Core
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批准号:7508857
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项目类别:
-
资助金额:$10.88万
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财政年份:2007
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负责人:ROBERT E. TIGELAAR
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依托单位:
Career Development Award Program
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批准号:8915626
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项目类别:
-
资助金额:$6.25万
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财政年份:2006
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负责人:ROBERT E. TIGELAAR
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依托单位:
CAREER DEVELOPMENT PROGRAM
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批准号:7147307
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项目类别:
-
资助金额:$6.54万
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财政年份:2006
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负责人:ROBERT E. TIGELAAR
-
依托单位:
Career Development Award Program
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批准号:8719050
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项目类别:
-
资助金额:$6.15万
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财政年份:2006
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负责人:ROBERT E. TIGELAAR
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依托单位:
DEVELOPMENTAL RESEARCH PROGRAM
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批准号:7147306
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项目类别:
-
资助金额:$14.37万
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财政年份:2006
-
负责人:ROBERT E. TIGELAAR
-
依托单位:
Career Development Award Program
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批准号:8389784
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项目类别:
-
资助金额:$6.56万
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财政年份:2006
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负责人:ROBERT E. TIGELAAR
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依托单位:
Developmental Research Program
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批准号:8389783
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项目类别:
-
资助金额:$9.37万
-
财政年份:2006
-
负责人:ROBERT E. TIGELAAR
-
依托单位:
Developmental Research Program
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批准号:8719049
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项目类别:
-
资助金额:$8.79万
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财政年份:2006
-
负责人:ROBERT E. TIGELAAR
-
依托单位:
Developmental Research Program
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批准号:8557724
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项目类别:
-
资助金额:$9.6万
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财政年份:2006
-
负责人:ROBERT E. TIGELAAR
-
依托单位:
Developmental Research Program
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批准号:9126437
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项目类别:
-
资助金额:$8.84万
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财政年份:2006
-
负责人:ROBERT E. TIGELAAR
-
依托单位:
Career Development Award Program
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批准号:8557725
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项目类别:
-
资助金额:$6.72万
-
财政年份:2006
-
负责人:ROBERT E. TIGELAAR
-
依托单位:
Core A - Administration (Robert Tigelaar, PI)
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批准号:6756346
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项目类别:
-
资助金额:$13.07万
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财政年份:2004
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负责人:ROBERT E. TIGELAAR
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依托单位:
Regulation of Cutaneous Inflammation by local gd T Cells
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批准号:6906535
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项目类别:
-
资助金额:$36.59万
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财政年份:2003
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负责人:ROBERT E. TIGELAAR
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依托单位:
Regulation of Cutaneous Inflammation by local gd T Cells
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批准号:6796239
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项目类别:
-
资助金额:$36.59万
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财政年份:2003
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负责人:ROBERT E. TIGELAAR
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依托单位:
Regulation of Cutaneous Inflammation by local gd T Cells
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批准号:7106514
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项目类别:
-
资助金额:$32.88万
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财政年份:2003
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负责人:ROBERT E. TIGELAAR
-
依托单位:
Regulation of Cutaneous Inflammation by local gd T Cells
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批准号:6681745
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项目类别:
-
资助金额:$38.08万
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财政年份:2003
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负责人:ROBERT E. TIGELAAR
-
依托单位:
Regulation of Cutaneous Inflammation by local gd T Cells
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批准号:7272780
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项目类别:
-
资助金额:$31.92万
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财政年份:2003
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负责人:ROBERT E. TIGELAAR
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依托单位:
ALPHA BETA T CELL INDEPENDENT B CELL FUNCTION
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批准号:2076048
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项目类别:
-
资助金额:$22.62万
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财政年份:1996
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负责人:ROBERT E. TIGELAAR
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依托单位:
ALPHA BETA T CELL INDEPENDENT B CELL FUNCTION
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批准号:2599415
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项目类别:
-
资助金额:$0.18万
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财政年份:1996
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负责人:ROBERT E. TIGELAAR
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依托单位:
海外基金