SPECIFICITY DISTRIBUTION & FUNCTION OF GAMMA DELTA T CEL

特异性分布

• 批准号: 3142138
• 负责人: ROBERT E. TIGELAAR
• 金额: $ 20.58万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3142138
• 关键词: CD8 molecule; MHC class I antigen; T cell receptor; T lymphocyte; antigen presentation; cellular immunity; gastrointestinal epithelium; gene expression; gut associated lymphoid tissue; hybridomas; interferons; interleukin 2; interleukin 4; laboratory mouse; leukocyte activation /transformation; microorganism immunology; polymerase chain reaction; protozoa; protozoal infection

In numbers, gamma delta T cells represent a significant component of the immune system in widely diverged vertebrates, including humans. Their function in the body remains, however, unknown. We proposed in 1988 that they were in large part responsible for the protection of surface epithelia against primary infection, reasoning that they may recognize 'stress' antigens. While much data supports this assessment, there is still very little data concerning what happens when animal epithelia are systematically infected. This study focuses on the response of gamma delta T cells to protozoans that infect animals across the vertebrate phylum. The experiments will be supported by others that will identify the proteins on other cells that are recognized by gamma delta T cells. Together, these experiments will help us understand how this newly-discovered set of lymphocytes helps protect animals from disease.

在数量上，γ δ T细胞代表了免疫系统的重要组成部分。 免疫系统在广泛分化的脊椎动物，包括人类。 他们的 然而，其在体内的功能仍然未知。 我们在1988年提出， 它们在很大程度上负责保护表面上皮细胞 对抗原发性感染，理由是他们可能认识到“压力” 抗原 虽然有很多数据支持这一评估，但仍有很多问题。 关于动物上皮细胞被 系统性感染 本研究的重点是伽玛δ的响应 从T细胞到感染脊椎动物门动物的原生动物。 这些实验将得到其他将鉴定蛋白质的实验的支持。 在其他被γ δ T细胞识别的细胞上。 所有这些 实验将帮助我们了解这组新发现的 淋巴细胞有助于保护动物免受疾病的侵害。