Understanding and Exploiting Tunicamycin (Bio)Synthesis to Enable Novel Antibiotics and Inhibitors

了解和利用衣霉素（生物）合成来开发新型抗生素和抑制剂

• 批准号: BB/J006637/1
• 负责人: Mervyn Bibb
• 金额: $ 46.99万
• 依托单位: John Innes Centre
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ006637%2F1
• 关键词: Understanding; Exploiting; Tunicamycin; Bio; Synthesis

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis Reveals New Insights into Tunicamycin Production and Immunity.

• DOI: 10.1128/aac.00130-18
• 发表时间: 2018-08
• 期刊: Antimicrobial agents and chemotherapy
• 影响因子: 4.9
• 作者: Widdick D;Royer SF;Wang H;Vior NM;Gomez-Escribano JP;Davis BG;Bibb MJ
• 通讯作者: Bibb MJ

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

• DOI: 10.1016/j.cell.2018.10.037
• 发表时间: 2018-11-01
• 期刊: Cell
• 影响因子: 64.5
• 作者: Dong YY;Wang H;Pike ACW;Cochrane SA;Hamedzadeh S;Wyszyński FJ;Bushell SR;Royer SF;Widdick DA;Sajid A;Boshoff HI;Park Y;Lucas R;Liu WM;Lee SS;Machida T;Minall L;Mehmood S;Belaya K;Liu WW;Chu A;Shrestha L;Mukhopadhyay SMM;Strain-Damerell C;Chalk R;Burgess-Brown NA;Bibb MJ;Barry Iii CE;Robinson CV;Beeson D;Davis BG;Carpenter EP
• 通讯作者: Carpenter EP