LONGITUDINAL STUDY OF A PRE-OSTEOPOROSIS POPULATION

该项目包括一项纵向、前瞻性的研究 骨质疏松的高危人群。研究对象为1914年正常 1967年研究开始时年龄在35-45岁之间的女性。观察 每五年制作一次，由全面的个人， 钙动力学、钙代谢、激素和生理学 测量，以及射线照相法和光子密度法 骨量的测量。超过120个主变量和派生变量是 积累了每一门学科的知识。 该项目的目的是：1)获得全面的纵向 有关钙代谢、骨代谢和 一组未接受治疗的妇女的相关生理功能 围绝经期至骨质疏松症状起病时间的中位数； 提供了一份详尽的生理档案， 有症状的骨质疏松症，以及那些没有症状的人，从而允许 对它们之间的差异和对 影响这些差异的因素；3)允许更好地识别 易患骨质疏松症的子集，从而为既提供合理的基础 用于预防性治疗和确定哪些对象应该 其目标是；4)描述两国之间的横向相互关系 骨质疏松症关键时期的主要生理变量 开发；最后5)为测试提供一个全面的数据库 我们和其他人提出的关于变量之间关联的假设 不在这项提议的背景下。 计划是继续我们对这群人的观察，直到有足够的 许多人患上了与骨质疏松相关的骨折。在新的一年开始 项目期间，研究人群的年龄范围为58-68岁。 33个可能与脆性相关的骨折发生在 到目前为止的队列。我们预计会看到更多这样的骨折 在接下来的五年期间发展。

This project consists of a longitudinal, prospective study of the population-at-risk for osteoporosis. Research subjects are 1914 normal women who were aged 35-45 at the start of the study in 1967. Observations are made once every five years and consist of comprehensive personal, calcium kinetic, calcium metabolic, hormonal, and physiological measurements, as well as radiogrammetric and photon-densitometric measurement of bone mass. Well over 120 primary and derived variables are accumulated on each subject. The purposes of the project are: 1) to obtain comprehensive longitudinal data on various measures of calcium metabolism, bone metabolism, and related physiological functions in a group of untreated women from the perimenopausal period to the median onset time of osteoporotic symptoms; 2) to provide an exhaustive physiological profile both on women who develop symptomatic osteoporosis, and on those who do not, thereby allowing prospective characterization of the differences between them and of the factor influencing those differences; 3) to permit better identification of the osteoporosis-prone subset and thereby to provide both a rational basis for prophylactic treatment and the identification of subjects who should be its target; 4) to characterize cross-sectional inter-relationships between major physiological variables during this key era of osteoporosis development; and finally 5) to provide a comprehensive database for testing hypotheses about associations among variables developed by us and others outside the context of this proposal. The plan is to continue our observations on this cohort until a sufficient number develop osteoporosis-related fractures. At the onset of the new project period the study population will be in the age-range 58-68. Thirty-three probable fragility-related fractures have occurred in the cohort to date. We anticipate seeing substantially more such fractures developing during this next five-year period.