LONGITUDINAL STUDY OF PREOSTEOPOROSIS POPULATION

描述：（改编自研究者摘要）该项目 包括对高危人群的纵向前瞻性研究 治疗骨质疏松症 研究对象为191名正常妇女， 35 - 45在1967年研究开始时。 我们已经观察到 每五年一次，包括人口统计学、人体测量学、钙 动力学、钙代谢、激素和生理测量， 以及骨的放射线测量和光子密度计测量 马萨诸塞州 该项目的目的是：（1）获得全面的纵向 钙和骨代谢的各种测量数据以及相关数据 一组未经治疗的妇女的生理功能， 围绝经期至出现腹泻症状的时间;（2）至 提供了一个详尽的生理资料， 随后发展为有症状骨质疏松症， 从而允许前瞻性地表征 （3）影响这些差异的因素;（4）允许 更好地识别易患糖尿病的亚群，从而 为预防性治疗提供了合理的依据， 确定目标对象;（4）确定 主要生理变量之间的横截面相互关系 在骨质疏松症发展的关键时期;最后（5） 提供一个全面的数据库，用于测试关于 申请人和其他人开发的变量之间的关联 在这个提议的范围之外。 下一个赠款期的计划是：（1）继续监测 直到有足够数量的骨质疏松相关骨折 发展，以及（2）继续获得主要结局指标（例如骨 骨折（每三年一次）。 在新项目开始时 研究人群的年龄范围为63 - 72岁。四十七 到目前为止，队列中发生了可能与脆性相关的骨折。

DESCRIPTION: (Adapted From Investigator's Abstract) This project consists of a longitudinal, prospective study of the population-at-risk for osteoporosis. Research subjects are 191 normal women who were aged 35-45 at the start of the study in 1967. Observations have been made once every five years consisting of demographic, anthropometric, calcium kinetic, calcium metabolic, hormonal, and physiological measurements, as well as radiogrammetric and photon-densitometer measurement of bone mass. The purposes of the project are: (1) to obtain comprehensive longitudinal data on various measures of calcium and bone metabolism and related physiological functions in a group of untreated women from the perimenopausal period to the time of osteoporotic symptoms; (2) to provide an exhaustive physiological profile both on women who subsequently develop symptomatic osteoporosis and on those who do not, thereby allowing prospective characterization of the differences between them and of the factors influencing those differences; (3) to permit better identification of the osteoporosis-prone subset and thereby to provide both a rational basis for prophylactic treatment and the identification of subjects who should be its target; (4) to characterize cross-sectional inter-relationships between major physiologic variables during this key era of osteoporosis development; and finally (5) to provide a comprehensive database for testing hypotheses about associations among variables developed by the applicants and others outside the context of this proposal. The plan for this next grant period is to: (1) maintain surveillance of this cohort until a sufficient number of osteoporosis-related fractures develop, and (2) to continue obtaining major outcome measures (e.g. bone mass, fractures) every three years. At the onset of the new project period the study population will be in the age-range 63-72. Forty-seven probably fragility-related fractures have occurred in the cohort to date.