LONGITUDINAL STUDY OF A PRE-OSTEOPOROSIS POPULATION

该项目包括一项纵向、前瞻性的研究 骨质疏松的高危人群。研究对象为184人正常 1967年研究开始时年龄在35-45岁之间的女性。观察 每五年制作一次，由全面的钙组成 动力学、钙代谢和生理测量，以及 骨量的放射照相和光子密度测量。总计 超过120个主要变量和派生变量在每个变量上累加 主题。我们的计划是继续这些观察，直到足够的 研究人群中的一小部分会出现脊椎挤压或其他 骨质疏松症相关骨折。在新的项目期开始时， 研究人群的年龄将在53-63岁之间，我们预计 开始看到与骨质疏松症相关的骨折在接下来的时间里发展 五年期。 该项目的目的是：1)获得全面的纵向 有关钙代谢、骨代谢和 一组未接受治疗的妇女的相关生理功能 围绝经期至骨质疏松症状起病时间的中位数； 提供了一份详尽的生理档案， 有症状的骨质疏松症，以及那些没有症状的人，从而允许 对它们之间的差异和对 影响这些差异的因素；3)允许更好地识别 易患骨质疏松症的亚群，从而提供合理的 预防性治疗的基础和对符合以下条件的受试者的识别 应该是它的目标；4)表征横截面 关键时期主要生理变量间的相互关系 骨质疏松时代的发展；最后为5)提供全面的 用于测试关于变量间关联的假设的数据库 由我们和其他人开发，不属于本协议的范围。

This project consists of a longitudinal, prospective study of the population-at-risk for osteoporosis. Research subjects are 184 normal women who were aged 35-45 at the start of the study in 1967. Observations are made once every five years and consist of comprehensive calcium kinetic, calcium metabolic, and physiological measurements, as well as radiogrammetric and photon-densitometric measurement of bone mass. A total of well over 120 primary and derived variables are accumulated on each subject. The plan is to continue these observations until a sufficient fraction of the study population develops vertebral crush or other osteoporosis-related fractures. At the onset of the new project period the study population will be in the age-range 53-63, and we anticipate beginning to see osteoporosis-related fractures developing during this next five-year period. The purposes of the project are: 1) to obtain comprehensive longitudinal data on various measures of calcium metabolism, bone metabolism, and related physiological functions in a group of untreated women from the perimenopausal period to the median onset time of osteoporotic symptoms; 2) to provide an exhaustive physiological profile both on women who develop symptomatic osteoporosis, and on those who do not, thereby allowing prospective characterization of the differences between them and of the factors influencing those differences; 3) to permit better identification of the osteoporosis-prone subset and thereby to provide both a rational basis for prophylactic treatment and the identification of subjects who should be its target; 4) to characterize cross-sectional inter-relationships between major physiological variables during this key era of osteoporosis development; and finally 5) to provide a comprehensive database for testing hypotheses about associations among variables developed by us and others outside the context of this protocol.