BONY EFFECTS OF TRANSIENT NONSKELETAL ILLNESS

描述（改编自申请人的摘要）：该项目旨在 量化的程度和时间过程中产生的骨质流失的发作， 一种与卧床休息和分解代谢有关的暂时性疾病 影响。 潜在的假设是， 这些情况往往是不完整的，特别是在关键地区 例如脊柱和髋部。 如果是真的，这意味着 年龄相关性骨质流失是一种间断性现象，与疾病和/或 固定化，而不是持续和无情。 这一发现 将为骨质疏松症的预防开辟更多的机会。 作为各种分解代谢事件的替代品， 将使用常规的，选择性的腹部或盆腔手术， 55-70岁的人。 他们将通过DEXA测量骨量， 术前、术后4-8周， 然后在第4、8和12个月时，量化和表征 在这种情况下会失去骨骼。 他们还将衡量各种 潜在修饰协变量，如暂时残疾程度、Ca 摄入量，激素治疗，维生素D状态，年龄和生活方式因素，任何 其中可能会影响骨质流失的程度或 复苏 他们将比较手术后不同时间点的下降情况 与基线值进行比较，并将 12个月，年龄和雌激素匹配的非手术对照组 替代疗法，并在12个月的间隔内测量两次。

DESCRIPTION (Adapted from the Applicant's Abstract): This project seeks to quantify the extent and time course of the bone loss produced by episodes of temporary illness of a sort associated with bed rest and catabolic influences. The underlying hypothesis is that recovery of bone lost under these circumstances is often incomplete, particularly in critical regions such as the spine and hip. If true, this would mean that some portion of age-related bone loss is a punctuated phenomenon, related to illness and/or immobilization, rather than being continuous and inexorable. This finding would open up additional opportunities for osteoporosis prevention. As a surrogate for a wide variety of catabolic episodes, the investigators will use routine, elective abdominal or pelvic surgery performed on individuals 55-70 years of age. They will measure bone mass by DEXA at spine and hip in 150 individuals before surgery, at 4-8 weeks post surgery, and then at 4, 8, and 12 months, to quantify and characterize the extent of bone lost under these circumstances. They will also measure various potentially modifying covariates, such as degree of temporary disability, Ca intake, hormonal therapy, vitamin D status, age, and life-style factors, any of which might plausibly influence extent of bone loss or degree of recovery. They will compare decreases at various time points after surgery to baseline values in each woman and will compare mean bone mass changes at 12 months with a non-operated control group matched for age and estrogen replacement therapy and measured twice across a 12-month interval.