The developmental logic of trigeminal sensory neurons

三叉神经感觉神经元的发育逻辑

• 批准号: BB/J015261/1
• 负责人: Anthony Graham
• 金额: $ 47.52万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ015261%2F1
• 关键词: developmental; logic; trigeminal; sensory; neurons

Sensory neurons relay information about our external environment to our central nervous system. The sensory neurons that project to our face and jaws, form part of trigeminal nerve, whose name derived from the fact that it has 3 branches; one branch projects to the forehead region, one to the upper jaw and one to the lower jaw. Many of these neurons are concerned with relaying information about heat, pain, and touch from the head to brain. Another group of trigeminal sensory neurons is additionally concerned with spatial information about the position of our jaw, which is important for mastication and speech. This same situation is seen in all jawed vertebrates.We know a lot about how sensory neurons develop in the trunk. They are found in the dorsal root ganglia, which form alongside the spinal cord. They arise from a single embryonic population called neural crest cells during early development and progress through a well-studied path to differentiate as sensory neurons. The situation with the trigeminal nerve is very different however - it is much more complex. The sensory neurons that are concerned with heat, pain and touch are found in the trigeminal ganglion, which does lie alongside the brain, but rather than being derived from a single embryonic population that are derived from 3 distinct populations. Many are derived from thickenings of the embryonic skin, the ophthalmic placode and the maxillomandibular placodes, as well as some from neural crest cells. In stark contrast to what is seen in the trunk, the neurons that transfer information about the spatial position of the jaw are not found in ganglia beside the central nervous system but are rather found within the brain itself. In the trunk, the neurons that monitor the position of the limbs also reside in the dorsal root ganglia.The aim of this research is to understand the significance of the developmental complexity that we find in the trigeminal system and to test the hypothesis that the embryonic origin of trigeminal sensory neurons matters. Preliminary data suggests that trigeminal sensory neurons send axons to different regions of the head. If this were true for all trigeminal neurons of different origins then this would allow us to demonstrate previously unknown complexity within the trigeminal system. This would have an impact for our understanding of the adult and aging situation. We will determine why the neurons that monitor the positioning of the jaw are sitting within the brain. We will also conduct an in depth comparison between the development of trigeminal and trunk sensory neurons to help us gain insights into the commonalities and differences that exits in the programme that lead to the formation of sensory neurons. Finally, we will also test if the motor neurons that control the movement of the jaw are also important in leading the axons of the sensory neurons that monitor its position to their correct location and how this is achieved

感觉神经元将我们外部环境的信息传递给中枢神经系统。感觉神经元，项目到我们的脸和下巴，形成三叉神经的一部分，其名称来源于它有3个分支的事实;一个分支项目到前额区域，一个到上颌和一个到下颌。这些神经元中的许多神经元负责将有关热、疼痛和触摸的信息从头部传递到大脑。另一组三叉神经感觉神经元还与关于我们下颌位置的空间信息有关，这对咀嚼和言语很重要。同样的情况在所有有颌脊椎动物身上都可以看到，我们对感觉神经元在躯干中的发育有很多了解。它们存在于背根神经节中，背根神经节与脊髓一起形成。它们在早期发育过程中从一个称为神经嵴细胞的胚胎群体中产生，并通过一条经过充分研究的途径分化为感觉神经元。然而，三叉神经的情况非常不同-它更加复杂。与热、疼痛和触觉有关的感觉神经元存在于三叉神经节中，三叉神经节确实位于大脑旁边，但不是来自来自3个不同种群的单个胚胎种群。许多是来自增厚的胚胎皮肤，眼基板和上下颌基板，以及一些来自神经嵴细胞。与在躯干中所看到的形成鲜明对比的是，传递有关下颌空间位置信息的神经元并不在中枢神经系统旁边的神经节中，而是在大脑本身中发现的。在躯干，神经元，监测的位置，四肢也居住在背根神经节。本研究的目的是了解的意义，我们发现在三叉神经系统的发展复杂性，并测试的假设，胚胎起源的三叉神经感觉神经元的事项。初步数据表明，三叉神经感觉神经元将轴突发送到头部的不同区域。如果这对所有不同起源的三叉神经元都是正确的，那么这将使我们能够证明三叉神经系统中以前未知的复杂性。这将对我们理解成人和老龄化情况产生影响。我们将确定为什么监控下颌位置的神经元位于大脑中。我们还将深入比较三叉神经和躯干感觉神经元的发育，以帮助我们深入了解导致感觉神经元形成的程序中存在的共性和差异。最后，我们还将测试控制下颌运动的运动神经元是否在引导监测其位置的感觉神经元的轴突到达正确位置方面也很重要，以及这是如何实现的

项目成果

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• DOI: 10.1038/nature17625
• 发表时间: 2016-04-07
• 期刊: Nature
• 影响因子: 64.8
• 作者: Moyes DL;Wilson D;Richardson JP;Mogavero S;Tang SX;Wernecke J;Höfs S;Gratacap RL;Robbins J;Runglall M;Murciano C;Blagojevic M;Thavaraj S;Förster TM;Hebecker B;Kasper L;Vizcay G;Iancu SI;Kichik N;Häder A;Kurzai O;Luo T;Krüger T;Kniemeyer O;Cota E;Bader O;Wheeler RT;Gutsmann T;Hube B;Naglik JR
• 通讯作者: Naglik JR

The Missing Link between Candida albicans Hyphal Morphogenesis and Host Cell Damage.

• DOI: 10.1371/journal.ppat.1005867
• 发表时间: 2016-10
• 期刊: PLoS pathogens
• 影响因子: 6.7
• 作者: Wilson D;Naglik JR;Hube B
• 通讯作者: Hube B

The emergence of mesencephalic trigeminal neurons.

• DOI: 10.1186/s13064-017-0088-z
• 发表时间: 2017-06-21
• 期刊: Neural development
• 影响因子: 3.6
• 作者: Lipovsek M;Ledderose J;Butts T;Lafont T;Kiecker C;Wizenmann A;Graham A
• 通讯作者: Graham A

Serotonin Receptor 1A (HTR1A), a Novel Regulator of GnRH Neuronal Migration in Chick Embryo.

血清素受体 1A (HTR1A)，鸡胚 GnRH 神经元迁移的新型调节剂。

• DOI: 10.1210/en.2016-1363
• 发表时间: 2016
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Poopalasundaram S