INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
批准号:
3150931
负责人:
STEPHEN J HERSEY
金额:
$15.25万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1976
资助国家:
美国
项目状态:
已结题
起止时间:
1976-12-01 至 1989-11-30
关键词:
acetylcholine acidity /alkalinity adenosine diphosphate cell membrane cellular pathology cellular respiration cyclic AMP cytochromes fluorimetry gastric mucosa gastrins histamine hydrochloric acid ion transport membrane permeability mitochondria mitochondrial membrane nicotinamide adenine dinucleotide oxidation reduction reaction oxidative phosphorylation secretion spectrometry stomach
中文摘要
这个计划的长期目标是描述细胞的序列,
导致胃酸分泌的反应
粘膜,重点是那些反应,作为主要的
控制步骤。 最近对这一领域的兴趣来自于
抗分泌剂在溃疡病临床治疗中的应用
认识到质子运输在各种
生物过程。
目前的建议旨在扩大以前关于
细胞控制酸分泌,以便提供更详细的
了解控制机制。 项目将利用
最近开发的离体胃腺制剂,
毛地黄皂苷透化细胞以及更传统的两栖动物
胃粘膜作为体外模型。 结合现代生物物理学,
生物化学和形态学技术将用于研究
蜂窝控制机制的选定方面。 主要领域是
研究内容包括:1)组胺H2-受体的调节; 2)组胺H2-受体的作用
蛋白激酶,特别是cAMP依赖性和
钙/磷脂依赖酶; 3)参与的基本机制
壁细胞的形态转变,
刺激; 4)线粒体代谢与
质子转运;和5)奥美拉唑,一种H-KATP酶抑制剂,
离子传输机制 这些领域被确定为重要的
监管场所,调查及时,承诺高
实现长期目标的进度。
英文摘要
The longterm goal of this program is to describe the sequence of cellular
reactions which lead to the secretion of hydrochloric acid by the gastric
mucosa with emphasis on those reactions which serve as the major
controlling steps. Recent interest in this area derives from the success
of antisecretory agents in the clinical management of ulcer disease and the
appreciation of the important role of proton transport in various
biological processes.
The current proposal seeks to extend previous observations concerning the
cellular control of acid secretion so as to provide a more detailed
understanding of the control mechanisms. Projects will utilize the
recently developed preparations of isolated gastric glands and
digitonin-permeabilized cells as well as the more traditional amphibian
gastric mucosa as in vitro models. A combination of modern biophysical,
biochemical, and morphological techniques will be used to investigate
selected aspects of cellular control mechanisms. The major areas to be
investigated include: 1) regulation of histamine H2-receptor; 2) the role
of protein kinases, specifically the cAMP-dependent and
calcium/phospholipid-dependent enzymes; 3) the basic mechanisms involved in
the morphological transition of the parietal cell which occurs with
stimulation; 4) the relationship between mitochondrial metabolism and
proton transport; and 5) the effects of omeprazole, an H-KATPase inhibitor,
on ion transport mechanisms. These areas are identified as important
regulatory sites, the investigation of which are timely and promises a high
rate of progress towards the longterm goal.
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DOI:
--
发表时间:
1981
期刊:
Federation proceedings
影响因子:
--
作者:
[Hersey,SJ]
通讯作者:
Hersey,SJ
pH dependence of pepsinogen and acid secretion in isolated gastric glands.
离体胃腺中胃蛋白酶原和酸分泌的 pH 依赖性。
DOI:
10.1152/ajpgi.1983.245.6.g730
发表时间:
1983
期刊:
The American journal of physiology
影响因子:
--
作者:
[Norris,SH, Hersey,SJ]
通讯作者:
Hersey,SJ
Inhibition of pepsinogen secretion in isolated gastric glands by amphotericin B is secretagogue specific.
两性霉素 B 对离体胃腺中胃蛋白酶原分泌的抑制是促分泌剂特异性的。
DOI:
10.1139/y84-251
发表时间:
1984
期刊:
Canadian journal of physiology and pharmacology
影响因子:
2.1
作者:
[Norris,SH, Hersey,SJ]
通讯作者:
Hersey,SJ
Acid secretion by frog gastric mucosa is electroneutral.
青蛙胃粘膜分泌的酸是电中性的。
DOI:
10.1152/ajpgi.1985.248.2.g246
发表时间:
1985
期刊:
The American journal of physiology
影响因子:
--
作者:
[Hersey,SJ, Sachs,G, Kasbekar,DK]
通讯作者:
Kasbekar,DK
Role of glucose metabolism in acid formation by isolated gastric glands.
葡萄糖代谢在离体胃腺酸形成中的作用。
DOI:
10.1016/0304-4165(82)90136-2
发表时间:
1982
期刊:
Biochimica et biophysica acta
影响因子:
--
作者:
[Hersey,SJ, Miller,M, Owirodu,A]
通讯作者:
Owirodu,A
共 17 条
REGULATORY MECHANISMS IN GASTRIC ENZYME SECRETION
-
批准号:3234996
-
项目类别:
-
资助金额:$15.28万
-
财政年份:1986
-
负责人:STEPHEN J HERSEY
-
依托单位:
REGULATORY MECHANISMS IN GASTRIC ENZYME SECRETION
-
批准号:3234995
-
项目类别:
-
资助金额:$14.21万
-
财政年份:1986
-
负责人:STEPHEN J HERSEY
-
依托单位:
REGULATORY MECHANISMS IN GASTRIC ENZYME SECRETION
-
批准号:3234994
-
项目类别:
-
资助金额:$14.46万
-
财政年份:1986
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225293
-
项目类别:
-
资助金额:$15.63万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225291
-
项目类别:
-
资助金额:$19.18万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225296
-
项目类别:
-
资助金额:$18.21万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225292
-
项目类别:
-
资助金额:$16.21万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225294
-
项目类别:
-
资助金额:$15.83万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:2136868
-
项目类别:
-
资助金额:$21.45万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225297
-
项目类别:
-
资助金额:$19.56万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225298
-
项目类别:
-
资助金额:$20.33万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位:
INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
-
批准号:3225295
-
项目类别:
-
资助金额:$16.87万
-
财政年份:1976
-
负责人:STEPHEN J HERSEY
-
依托单位: