INTRACELLULAR REACTIONS IN GASTRIC MUCOSA
胃粘膜的细胞内反应
基本信息
- 批准号:3225294
- 负责人:
- 金额:$ 15.83万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1976
- 资助国家:美国
- 起止时间:1976-12-01 至 1989-11-30
- 项目状态:已结题
- 来源:
- 关键词:Anura acetylcholine acidity /alkalinity adenosine diphosphate cell membrane cellular pathology cellular respiration cyclic AMP cytochromes fluorimetry gastric mucosa gastrins histamine histamine receptor hydrochloric acid ion transport membrane permeability mitochondria mitochondrial membrane nicotinamide adenine dinucleotide oxidation reduction reaction oxidative phosphorylation secretion spectrometry stomach transport proteins
项目摘要
The longterm goal of this program is to describe the sequence of cellular
reactions which lead to the secretion of hydrochloric acid by the gastric
mucosa with emphasis on those reactions which serve as the major
controlling steps. Recent interest in this area derives from the success
of antisecretory agents in the clinical management of ulcer disease and the
appreciation of the important role of proton transport in various
biological processes.
The current proposal seeks to extend previous observations concerning the
cellular control of acid secretion so as to provide a more detailed
understanding of the control mechanisms. Projects will utilize the
recently developed preparations of isolated gastric glands and
digitonin-permeabilized cells as well as the more traditional amphibian
gastric mucosa as in vitro models. A combination of modern biophysical,
biochemical, and morphological techniques will be used to investigate
selected aspects of cellular control mechanisms. The major areas to be
investigated include: 1) regulation of histamine H2-receptor; 2) the role
of protein kinases, specifically the cAMP-dependent and
calcium/phospholipid-dependent enzymes; 3) the basic mechanisms involved in
the morphological transition of the parietal cell which occurs with
stimulation; 4) the relationship between mitochondrial metabolism and
proton transport; and 5) the effects of omeprazole, an H-KATPase inhibitor,
on ion transport mechanisms. These areas are identified as important
regulatory sites, the investigation of which are timely and promises a high
rate of progress towards the longterm goal.
这个程序的长期目标是描述细胞的序列
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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STEPHEN J HERSEY的其他文献
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{{ truncateString('STEPHEN J HERSEY', 18)}}的其他基金
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