Translational investigation of a lithium mimetic on emotional and cognitive processing in healthy volunteers

锂模拟物对健康志愿者情绪和认知处理的转化研究

• 批准号: BB/J021547/1
• 负责人: Grant Churchill
• 金额: $ 19.39万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FJ021547%2F1
• 关键词: Translational; investigation; lithium; mimetic; emotional

Bipolar disorder disease is a chronic illness characterized by recurrent episodes of aberrant mood that affects around 3% of the world's population. Current therapies for bipolar disorder such as lithium, valproic acid and atypical antipsychotics, such as seroquel, cause serious side effects including liver and kidney damage. There is therefore an urgent need for new therapies that allow long-term mood stabilisation in patients, but are more favourably tolerable. In this project, we propose to confirm the suitability of a known antioxidant that has proven to be safe in humans as a lithium replacement candidate. Our drug inhibits the enzyme inositol monophosphatase, a candidate therapeutic target of lithium and also alters mood and behaviour in animals in a manner similar to lithium. This drug, if successful therefore, would offer for the first time, the potential for physicians to treat bipolar patients without exposing them to harmful side effects.

双相情感障碍是一种慢性疾病，其特征是反复发作的异常情绪，影响世界上约3%的人口。目前用于双相情感障碍的疗法，如锂、丙戊酸和非典型抗精神病药，如思瑞康，会引起严重的副作用，包括肝和肾损伤。因此，迫切需要允许患者长期情绪稳定，但更有利地耐受的新疗法。在这个项目中，我们建议确认一种已知的抗氧化剂的适用性，该抗氧化剂已被证明是安全的，可作为锂替代候选物。我们的药物抑制肌醇单磷酸酶，这是锂的候选治疗靶点，也以类似于锂的方式改变动物的情绪和行为。因此，这种药物如果成功，将首次为医生提供治疗双相情感障碍患者而不使他们暴露于有害副作用的可能性。

项目成果

Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.

• DOI: 10.1007/s00213-016-4319-5
• 发表时间: 2016-07
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Masaki C;Sharpley AL;Cooper CM;Godlewska BR;Singh N;Vasudevan SR;Harmer CJ;Churchill GC;Sharp T;Rogers RD;Cowen PJ
• 通讯作者: Cowen PJ

Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla.

• DOI: 10.1007/s00213-015-4189-2
• 发表时间: 2016-03
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Masaki C;Sharpley AL;Godlewska BR;Berrington A;Hashimoto T;Singh N;Vasudevan SR;Emir UE;Churchill GC;Cowen PJ
• 通讯作者: Cowen PJ

Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

• DOI: 10.1038/npp.2015.343
• 发表时间: 2016-06
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Singh N;Sharpley AL;Emir UE;Masaki C;Herzallah MM;Gluck MA;Sharp T;Harmer CJ;Vasudevan SR;Cowen PJ;Churchill GC
• 通讯作者: Churchill GC

A safe lithium mimetic for bipolar disorder.

• DOI: 10.1038/ncomms2320
• 发表时间: 2013
• 期刊: Nature communications
• 影响因子: 16.6