CONTROL OF COLONIC MOTILITY IN HEALTH AND DISEASE

这项研究建议的总体目标是阐明 结肠控制的肌源性、神经和激素控制机制 健康和疾病中的运动功能。特别强调的是 结肠的循环运动和肌电活动，其机制 这些循环活动的启动和传播，其影响 控制，低纤维和高纤维日粮对这些活动的耦合 结肠电活动和收缩活动之间的关系，以及 部分药物和多肽对结肠电和结肠的影响 收缩活动。 这些实验将在清醒和麻醉的狗身上进行，使用 植入应变片和电极，并在人体上使用腔内 安装有吸盘电极和应变计的记录管 元素。神经在控制结肠运动中的作用将是 用神经切断术和电刺激技术研究 太紧张了。电活动和收缩活动之间的耦合以及 药物的作用将通过闭合动脉内进行研究 灌流和系统性管理。数据将通过以下方式进行分析 计算机和/或电子过滤和可视。 我们的长期目标是应用所获得的知识和理解 从动物实验到人类结肠运动功能的研究 健康和各种病理状态，如肠易激综合征， 特发性假性肠梗阻和憩室病。一个 对肌源性、神经和激素控制功能的洞察 健康和结肠动力障碍的机制将是必不可少的 提出适当的药物、治疗和手术措施 在疾病中使结肠运动功能正常化。

The overall objective of this research proposal is to elucidate the myogenic, neural and hormonal control mechanisms for the control of colonic motor function in health and disease. Particular emphasis is laid on the cyclic motor and myoelectrical activities in the colon, the mechanisms of intiation and propagation of these cyclic activities, the effects of control, low fiber and high fiber diets on these activities, the coupling between colonic electrical and contractile activities, and the effects of some selected pharmacologic agents and peptides on colonic electrical and contractile activities. The experiments will be done on conscious and anesthetized dogs using implanted strain gauges and electrodes and on humans using intraluminal recording tubes mounted with suction cup electrodes and strain gauge elements. The role of nerves in the control of colonic motility will be studied by the techniques of nerve section and electrical stimulation of nerves. The coupling between electrical and contractile activities and the effect of pharmacological agents will be studied by close intraarterial perfusions and systemic administrations. The data will be analysed by computer and/or electronic filtering and visually. Our long term goal is to apply the knowledge and understanding obtained from animal experiments to the study of human colonic motor function in health and in various pathological states such as irritable bowel syndrome, idiopathic intestinal pseudoobstruction, and diverticular disease. An insight into the functioning of the myogenic, neural and hormonal control mechanisms in health and in colonic motility disorders will be essential to propose appropriate pharmacological, therapeutical and surgical measures to normalize colonic motor function in disease.