COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
批准号:
3155635
负责人:
SHELDON R PINNELL
金额:
$13.8万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1981
资助国家:
美国
项目状态:
已结题
起止时间:
1981-04-01 至 1993-11-30
关键词:
aging ascorbate cell adhesion cell differentiation collagen connective tissue disorder connective tissue metabolism enzyme linked immunosorbent assay fibroblasts genetic library genetic transcription glycosylation human subject human tissue laboratory rabbit messenger RNA proline protein biosynthesis skin tissue /cell culture transforming growth factors wound healing
中文摘要
胶原蛋白是体内的主要结构蛋白,具有重要的作用
在分化等多种生物功能中发挥着重要作用,
重塑、伤口修复和衰老。 培养中的人皮肤成纤维细胞
将大部分蛋白质合成能力投入到胶原蛋白中,
从而为研究胶原蛋白的调节提供了一个方便的系统
合成。 我们正在进行的研究涉及监管
胶原蛋白基因以及胶原蛋白特异性酶的表达
脯氨酰羟化酶和赖氨酰羟化酶,特别是关于
抗坏血酸(一种胶原蛋白合成诱导剂)和米诺地尔(一种药物)
我们最近发现可以特异性抑制赖氨酰的合成
羟化酶。 我们提出旨在了解其机制的研究
这些效应是在分子水平上产生的。
英文摘要
Collagen is the major structural protein in the body and one that plays an
important role in such diverse biological functions as differentiation,
remodeling, wound repair, and aging. Human skin fibroblasts in culture
devote a large portion of their protein synthetic capacity to collagen,
thus providing a convenient system for studying regulation of collagen
synthesis. Our ongoing studies are concerned with regulation of the
expression of collagen genes as well as the collagen-specific enzymes
prolyl hydroxylase and lysyl hydroxylase, especially with respect to
ascorbic acid, an inducer of collagen synthesis, and minoxidil, a drug that
we have recently found to specifically inhibit the synthesis of lysyl
hydroxylase. We propose studies designed to understand the mechanism of
these effects at the molecular level.
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会议论文
Photoprotection of Skin by Novel Polyphenol Antioxidants
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批准号:6691497
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项目类别:
-
资助金额:$9.63万
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财政年份:2003
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负责人:SHELDON R PINNELL
-
依托单位:
Development of a New Topical Antifungal Agent
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批准号:7089935
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项目类别:
-
资助金额:$8.39万
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财政年份:2002
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负责人:SHELDON R PINNELL
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依托单位:
Development of a New Topical Antifungal Agent
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批准号:6880404
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项目类别:
-
资助金额:$66.07万
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财政年份:2002
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负责人:SHELDON R PINNELL
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依托单位:
Development of a New Topical Antifungal Agent
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批准号:6548978
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项目类别:
-
资助金额:$10.7万
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财政年份:2002
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负责人:SHELDON R PINNELL
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依托单位:
CHARACTERIZATION OF GENES FOR HUMAN TYPE I COLLAGEN
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批准号:3152320
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项目类别:
-
资助金额:$10.55万
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财政年份:1983
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负责人:SHELDON R PINNELL
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依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:2683262
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项目类别:
-
资助金额:$16.35万
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财政年份:1981
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负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:3155633
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项目类别:
-
资助金额:$12.52万
-
财政年份:1981
-
负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:3151876
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项目类别:
-
资助金额:$13.63万
-
财政年份:1981
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负责人:SHELDON R PINNELL
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依托单位:
COLLAGEN BIOSYNTHESIS IN SKIN FIBROBLASTS
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批准号:2078643
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项目类别:
-
资助金额:$15.56万
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财政年份:1981
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负责人:SHELDON R PINNELL
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依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:2899834
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项目类别:
-
资助金额:$16.77万
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财政年份:1981
-
负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN SKIN FIBROBLASTS
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批准号:2078642
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项目类别:
-
资助金额:$15.14万
-
财政年份:1981
-
负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:3155631
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项目类别:
-
资助金额:$12.96万
-
财政年份:1981
-
负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:3155632
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项目类别:
-
资助金额:$14.55万
-
财政年份:1981
-
负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:2390483
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项目类别:
-
资助金额:$15.94万
-
财政年份:1981
-
负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:3155636
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项目类别:
-
资助金额:$14.23万
-
财政年份:1981
-
负责人:SHELDON R PINNELL
-
依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
-
批准号:3155634
-
项目类别:
-
资助金额:$13.09万
-
财政年份:1981
-
负责人:SHELDON R PINNELL
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依托单位:
COLLAGEN BIOSYNTHESIS IN HUMAN SKIN FIBROBLASTS
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批准号:3155628
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项目类别:
-
资助金额:$12.52万
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财政年份:1981
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负责人:SHELDON R PINNELL
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依托单位:
COLLAGEN BIOSYNTHESIS IN CONNECTIVE TISSUE DISEASE
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批准号:3151042
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项目类别:
-
资助金额:$18.51万
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财政年份:1978
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负责人:SHELDON R PINNELL
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依托单位:
COLLAGEN BIOSYNTHESIS IN CONNECTIVE TISSUE DISEASE
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批准号:3154927
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项目类别:
-
资助金额:$18.08万
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财政年份:1978
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负责人:SHELDON R PINNELL
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依托单位:
COLLAGEN BIOSYNTHESIS IN CONNECTIVE TISSUE DISEASE
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批准号:2078350
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项目类别:
-
资助金额:$35.3万
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财政年份:1978
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负责人:SHELDON R PINNELL
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依托单位:
海外基金