Development of a New Topical Antifungal Agent

新型外用抗真菌剂的开发

• 批准号: 6548978
• 负责人: SHELDON R PINNELL
• 金额: $ 10.7万
• 依托单位: SKINRESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6548978
• 关键词: Ascomycetes; antifungal agents; drug design /synthesis /production; drug screening /evaluation; guinea pigs; polyethylene glycols; skin infection; surfactant; swine; topical drug application; water solubility

DESCRIPTION (provided by applicant): A novel antifungal chemical has been identified that is capable of killing Trichophyton rubrum with high sensitivity. The substance is highly water soluble, nontoxic, widely available, and relatively inexpensive. It may be useful as a topical treatment for fungal infections of skin and nails. We will test its effectiveness against a battery of fungi, explore the antifungal capabilities of similar chemicals and test its effectiveness in a guinea pig dermatophyte skin infection model. If successful, we will plan to test its effectiveness against fungal infections in humans. PROPOSED COMMERCIAL APPLICATION: Fungal infections of skin and nails are extremely common, affecting greater than 20% of the population, and over 50% of elderly. Fungal infections are particularly aggressive and dangerous in immunosuppressed, debilitated, and elderly persons. Fungal infections are especially difficult to treat, usually requiring oral medication. New, effective topical therapies for fungal skin infections are needed and would be widely used.

描述(由申请人提供)：一种新的抗真菌化学物质已被鉴定，能够高敏感性地杀死红色毛霉菌。这种物质高度水溶性，无毒，可广泛获得，而且相对便宜。它可能是一种局部治疗皮肤和指甲真菌感染的有效方法。我们将测试其对一系列真菌的有效性，探索类似化学物质的抗真菌能力，并在豚鼠皮肤真菌感染模型中测试其有效性。如果成功，我们将计划测试其对人类真菌感染的有效性。 建议的商业应用：皮肤和指甲的真菌感染非常常见，影响超过20%的人口和超过50%的老年人。真菌感染在免疫抑制、虚弱和老年人中尤其具有侵袭性和危险性。真菌感染特别难治疗，通常需要口服药物。治疗真菌皮肤感染的新的、有效的局部疗法是必要的，并将被广泛使用。