INTERNAL AND EXTERNAL DEFORMATIONS OF THE LUMBAR DISC

腰椎间盘的内部和外部变形

• 批准号: 3158665
• 负责人: MARTIN H KRAG
• 金额: $ 20.13万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-02-01 至 1992-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3158665
• 关键词: back injury; biomechanics; chronic disease /disorder; human tissue; intervertebral disk; mathematical model; skeletal stress

The intervertebral disc is important for both normal spine function, as well as for a variety of significant spine abnormalities, an important example of which is low back pain: there are 2.5 million low back injured and 1.2 million low back disabled adults in the U.S.; low back injury total compensation costs were estimated to be $2.7 billion in 1978. Critical to our understanding of this problem is the biomechanics of the intervertebral disc. We propose to further this understanding by measuring the internal deformations of the disc as a result of motion between adjacent vertebrae. No previous quantitative work has been reported on internal disc deformations other than preliminary work from this laboratory. The major goals of the proposed work are as follows: 1. For the interior of human lumbar intervertebral discs, to describe the biomechanical behavior (displacement distribution and intranuclear pressure) produced by each of 3 controlled intervertebral displacements (compression, flexion, extension), for each of 4 different disc states (normal intact, normal with annulotomy, normal denucleated, and degenerated intact), using unembalmed cadaveric excised motion segments in vitro. The measurement techniques used include a) small metallic beads implanted in a regular array within the disc, by means of a special stereotoxic instrument and hypodermic needle, b) sagittal view x- rays to record bead displacements, c) specially-designed Hall- effect transducers to record strain along the periphery of the disc, d) pressure recording from the center of the nucleus pulposus, and e) an MTS machine to impose controlled displacements upon the upper vertebra of the motion segment and to record the resulting forces. 2. For each of these 4 disc states, to compare the experimentally measured displacements to those displacements predicted by four 2-D finite element models (isotropic, orthotropic, hydrostatic, poroelastic). Each model will use as input the actual geometry of the individual disc specimens and the vertebral displacements imposed upon them. By comparing the experimental data and the model predictions several hypotheses may be tested concerning the relationship between model type and disc state.

椎间盘对于正常脊柱都很重要 功能，以及对各种重要的脊柱 异常，其中一个重要的例子是腰痛： 有250万人腰部受伤，120万人腰部受伤 美国的残疾成年人；腰伤总赔偿 1978 年的成本估计为 27 亿美元。对我们来说至关重要 对这个问题的理解是生物力学 椎间盘。 我们建议通过以下方式进一步加深这种理解： 测量圆盘的内部变形 相邻椎骨之间的运动。 之前没有定量 已经报道了除椎间盘内部变形以外的其他工作 该实验室的初步工作。 拟议工作的主要目标如下： 1.对于人体腰椎间盘内部， 描述生物力学行为（位移分布 和核内压力）由 3 个受控的每一个产生 椎间位移（压缩、屈曲、伸展）， 4 种不同的椎间盘状态（正常完整、正常带 环切术，正常去核，和完整退化），使用 未防腐的尸体在体外切除的运动节段。 使用的测量技术包括 a) 小金属珠 通过特殊的方式植入椎间盘内的规则阵列中 立体毒性仪器和皮下注射针，b) 矢状视图 x- 射线记录珠位移，c）专门设计的霍尔- 效应传感器记录沿周边的应变 圆盘，d) 从核中心记录压力 e) 一台 MTS 机器来施加受控的 运动节段上椎骨上的位移和 记录由此产生的力。 2. 对于这 4 个光盘状态中的每一个，通过实验比较 测量的位移与四个预测的位移 二维有限元模型（各向同性、正交各向异性、静液压、 多孔弹性）。 每个模型将使用实际几何形状作为输入 各个椎间盘标本和椎骨位移 强加给他们。 通过比较实验数据和模型预测 可以检验有关关系的几个假设 模型类型和光盘状态之间。