MUSCLE DAMAGE IN AGING--INFLAMMATORY MECHANISMS

即使是中等强度的不习惯的肌肉活动也会导致 在一定程度上损害收缩蛋白和 伴生结缔组织。偏心运动，其中肌肉 随着紧张的发展而延长，是大多数形式的自然部分 是运动的一部分，是一种特别有效的损害诱因。一个 炎症反应与这种肌肉损伤有关， 可能有助于分解代谢过程，并可能调节肌肉 蛋白质翻转负责修复。我们建议使用 偏心运动以检查年龄相关的差异 与肌肉损伤相关的炎症反应。这个 炎症反应将在血液和骨骼中进行测量 肌肉。循环免疫复合体，功能性补体 活性、白介素L、体液坏死因子和 体液细胞毒性因子将被检测。在肌肉方面，人类白细胞抗原级别 I抗原、IL-L、肿瘤坏死因子浓度和受体数目 并对其免疫组织学特征进行研究 入侵的白细胞将被执行。非物质文化遗产的影响 类固醇抗炎药消炎痛及其影响 膳食中补充omega-3脂肪酸对所有这些 参数也将被评估。通过检查系统和 与破坏性运动有关的肌肉内过程， 可能是至关重要的修复效应器的机制 青年和老年受试者的外围训练将是 第一次以此为特征。这项研究将把 检查肌肉损伤反应的新方法和 区分年轻人和老年人。这些数据将是 对运动员很重要，但对运动员来说可能更重要 数以百万计的老年人和年轻人开始了一项增加 体力活动。此外，该偏心训练方案可以 证明是一种安全、可控的替代实验模型 用于研究老年人的炎症。

Unaccustomed muscular activity of even moderate intensity results in a certain amount of damage to contractile proteins and associated connective tissue. Eccentric exercise, in which muscles lengthen as they develop tension, is a natural part of most forms of exercise and is a particularly potent inducer of damage. An inflammatory response is associated with this muscle damage which might contribute to catabolic processes and may mediate muscle protein turn over responsible for repair. We propose to use eccentric exercise to examine age-related differences in the inflammatory response associated with muscle damage. The inflammatory response will be measured in blood and in skeletal muscle. Circulating immune complexes, functional complement activity, interleukin-l (IL-l), humor necrosis factor (TNF), and humoral cytotoxic factors will be measured. In muscle, HLA class I antigens, IL-l, and TNF concentrations and receptor numbers will be determined and the immunohistological characterization of invading leukocytes will be performed. The influence of the non- steroidal anti-inflammatory drug indomethacin, and the influence of dietary omega-3 fatty acid supplementation on all of these parameters will be assessed as well. By examining the systemic and intramuscular processes involved in damaging exercise, the mechanisms which may be critically important effectors of repair and peripheral training in young and old subjects will be characterized for the first time. This study will bring together novel methods to examine responses to muscle damage and differentiate between the young and the old. These data will be important for the athlete, but perhaps more important for the millions of old and young people beginning a program of increased physical activity. Moreover, the eccentric exercise protocol may prove to be a safe and controlled alternative experimental model for studying inflammation the elderly.