EXERTION-INDUCED CYTOKINES IN CHRONIC FATIGUE SYNDROME

慢性疲劳综合征中劳累诱导的细胞因子

• 批准号: 3148469
• 负责人: JOSEPH G CANNON
• 金额: $ 19.27万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3148469
• 关键词: attitude; body temperature; chronic fatigue syndrome; complement; cytokine; cytokine receptors; elastases; exercise; female; human subject; inhibitor /antagonist; interleukin 1; leukocyte activation /transformation; neutrophil; pain; protein biosynthesis; tumor necrosis factor alpha

DESCRIPTION (Investigator's abstract): This application is intended to test the hypothesis that the fever, fatigue and myalgia experienced by some patients with chronic fatigue syndrome (CFS) are due to abnormal cytokine production and leukocyte activity. Cytokines such as interleukin 1B (IL-1B) and tumor necrosis factor-a (TNFa) mediate fever and metabolic adaptations during infection. Exercise enhances production of these cytokines in healthy individuals, but an altered response may account for the exertionally-induced clinical signs and symptoms in CFS patients. In this study, cytokine production, along with associated leukocyte functions and metabolic responses will be measured before and after exercise in CFS patients and control subjects. A demonstration of abnormal cytokine production after exercise could help to explain the pathogenesis of an illness that at present is poorly understood. In addition, such information may lead to effective therapy; cytokine production can be influenced by dietary modifications, and cytokine activity can be altered by receptor antagonists and soluble receptors that are currently undergoing clinical trials.

描述(调查人员摘要)：此应用程序旨在 来检验发烧、疲劳和肌肉疼痛 一些慢性疲劳综合征(CFS)患者经历过的 由于细胞因子的产生和白细胞的异常活动。细胞因子 如白介素1B(IL-1B)和肿瘤坏死因子-a(TNFa) 在感染期间调节发烧和代谢适应。锻炼 增强健康个体中这些细胞因子的产生，但 反应的改变可能解释了体力衰竭引起的临床症状 慢性疲劳综合征患者的体征和症状。在这项研究中，细胞因子的产生， 以及相关的白细胞功能和新陈代谢反应 慢性疲劳综合征患者和对照组运动前后的测量 研究对象。细胞因子产生异常的一种表现 运动可以帮助解释一种疾病的发病机制 人们对目前的情况知之甚少。此外，此类信息可能会导致 有效的治疗；细胞因子的产生会受到饮食的影响 修饰，细胞因子活性可以通过受体改变 目前正在进行临床试验的拮抗剂和可溶性受体 审判。