EXERTION-INDUCED CYTOKINES IN CHRONIC FATIGUE SYNDROME

慢性疲劳综合征中劳累诱导的细胞因子

• 批准号: 2068413
• 负责人: JOSEPH G CANNON
• 金额: $ 16.9万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-04-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2068413
• 关键词: attitude; body temperature; chronic fatigue syndrome; complement; cytokine; cytokine receptors; elastases; exercise; female; human subject; inhibitor /antagonist; interleukin 1; leukocyte activation /transformation; neutrophil; pain; protein biosynthesis; tumor necrosis factor alpha

DESCRIPTION (Investigator's abstract): This application is intended to test the hypothesis that the fever, fatigue and myalgia experienced by some patients with chronic fatigue syndrome (CFS) are due to abnormal cytokine production and leukocyte activity. Cytokines such as interleukin 1B (IL-1B) and tumor necrosis factor-a (TNFa) mediate fever and metabolic adaptations during infection. Exercise enhances production of these cytokines in healthy individuals, but an altered response may account for the exertionally-induced clinical signs and symptoms in CFS patients. In this study, cytokine production, along with associated leukocyte functions and metabolic responses will be measured before and after exercise in CFS patients and control subjects. A demonstration of abnormal cytokine production after exercise could help to explain the pathogenesis of an illness that at present is poorly understood. In addition, such information may lead to effective therapy; cytokine production can be influenced by dietary modifications, and cytokine activity can be altered by receptor antagonists and soluble receptors that are currently undergoing clinical trials.

描述（研究者摘要）：本申请是有意的