EXERTION-INDUCED CYTOKINES IN CHRONIC FATIGUE SYNDROME

描述（研究者摘要）： 本申请意 来验证发烧疲劳和肌痛 慢性疲劳综合征（CFS）患者的一些经验是 由于异常的细胞因子产生和白细胞活性。 细胞因子 如白细胞介素1B（IL-1B）和肿瘤坏死因子-α（TNF α）， 在感染期间介导发热和代谢适应。 行使 在健康个体中增强这些细胞因子的产生，但是 改变的反应可以解释运动诱导的临床 CFS患者的症状和体征。 在这项研究中，细胞因子的产生， 沿着相关的白细胞功能和代谢反应将 在CFS患者和对照组运动前后进行测量 科目 一个异常的细胞因子生产的证明后， 运动可以帮助解释一种疾病的发病机制， 目前还不太了解。 此外，这些信息可能导致 有效的治疗;细胞因子的产生可以受到饮食的影响， 细胞因子的活性可以被受体修饰而改变。 拮抗剂和可溶性受体，目前正在进行临床 审判

DESCRIPTION (Investigator's abstract): This application is intended to test the hypothesis that the fever, fatigue and myalgia experienced by some patients with chronic fatigue syndrome (CFS) are due to abnormal cytokine production and leukocyte activity. Cytokines such as interleukin 1B (IL-1B) and tumor necrosis factor-a (TNFa) mediate fever and metabolic adaptations during infection. Exercise enhances production of these cytokines in healthy individuals, but an altered response may account for the exertionally-induced clinical signs and symptoms in CFS patients. In this study, cytokine production, along with associated leukocyte functions and metabolic responses will be measured before and after exercise in CFS patients and control subjects. A demonstration of abnormal cytokine production after exercise could help to explain the pathogenesis of an illness that at present is poorly understood. In addition, such information may lead to effective therapy; cytokine production can be influenced by dietary modifications, and cytokine activity can be altered by receptor antagonists and soluble receptors that are currently undergoing clinical trials.