Role of the inter-fascicular matrix in age related deterioration of tendon mechanical function

束间基质在年龄相关肌腱机械功能恶化中的作用

• 批准号: BB/K008781/1
• 负责人: Graham Riley
• 金额: $ 0.66万
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FK008781%2F1
• 关键词: Role; inter; fascicular; matrix; age

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前，GtR 中尚未提供所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但可能是因为它包含个人详细信息等敏感信息。

项目成果

Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation.

• DOI: 10.1074/jbc.m114.566554
• 发表时间: 2014-09-12
• 期刊: The Journal of biological chemistry
• 作者: Peffers MJ;Thorpe CT;Collins JA;Eong R;Wei TK;Screen HR;Clegg PD
• 通讯作者: Clegg PD

Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition.

• DOI: 10.1038/srep20455
• 发表时间: 2016-02-04
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Thorpe CT;Peffers MJ;Simpson D;Halliwell E;Screen HR;Clegg PD
• 通讯作者: Clegg PD

Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons.

束和丝间基质显示适应能量存储肌腱疲劳性的适应性。

• DOI: 10.1016/j.actbio.2016.06.012
• 发表时间: 2016-09-15
• 期刊: ACTA BIOMATERIALIA
• 影响因子: 9.7
• 作者: Thorpe, Chavaunne T.;Riley, Graham P.;Birch, Helen L.;Clegg, Peter D.;Screen, Hazel R. C.
• 通讯作者: Screen, Hazel R. C.

The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons.

• DOI: 10.1016/j.jmbbm.2015.04.009
• 发表时间: 2015-12
• 期刊: Journal of the mechanical behavior of biomedical materials
• 影响因子: 3.9
• 作者: Thorpe CT;Godinho MSC;Riley GP;Birch HL;Clegg PD;Screen HRC
• 通讯作者: Screen HRC