ANALYSIS OF THE SHOPE PAPILLOMA-CARCINOMA SYSTEM

SHOPE 乳头状瘤-癌系统的分析

• 批准号: 3164873
• 负责人: FELIX O WETTSTEIN
• 金额: $ 15.71万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-30 至 1987-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3164873
• 关键词: Shope papilloma; affinity chromatography; carcinoma; cell differentiation; clone cells; cocarcinogen; density gradient ultracentrifugation; gel electrophoresis; genetic manipulation; genetic translation; host neoplasm interaction; immunochemistry; immunofluorescence technique; neoplasm /cancer immunology; rabbit papillomavirus; radiotracer; simian virus 40; viral carcinogenesis; virus DNA; virus RNA; virus antigen; virus genetics; virus replication

The Shope papilloma-carcinoma system has great potential in the definition of basic phenomena associated with the neoplastic process. This is true since, in the domestic rabbit there is a viral induced progression from normal skin to papillomas to carcinomas. The viral genome is conserved in all neoplasms, but virus is not made. We propose to qualitatively and quantitatively determine the extent to which viral gene products are present in the two neoplasms. This beginning effort should ultimately lead to a definition of the precise role of the virus and its gene products in induction and maintenance of benign and malignant neoplasms.

Shope乳头状瘤-癌系统在肿瘤的定义上有很大的潜力

项目成果

Integrated shope virus DNA is present and transcribed in the transplantable rabbit tumour Vx-7.

整合的 Shope 病毒 DNA 存在于可移植兔肿瘤 Vx-7 中并进行转录。

• DOI: 10.1099/0022-1317-60-2-271
• 发表时间: 1982
• 期刊: The Journal of general virology
• 作者: McVay,P;Fretz,M;Wettstein,F;Stevens,J;Ito,Y
• 通讯作者: Ito,Y

Transcription of the viral genome in papillomas and carcinomas induced by the Shope virus.

肖普病毒诱导的乳头状瘤和癌中病毒基因组的转录。

• DOI: 10.1016/0042-6822(81)90517-1
• 发表时间: 1981
• 期刊: Virology
• 影响因子: 3.7
• 作者: Wettstein,FO;Stevens,JG
• 通讯作者: Stevens,JG