CANCER EPIDEMIOLOGY OF THE MIGRANT JAPANESE IN HAWAII

这是一项对8006名日本血统男性的前瞻性研究， 出生于1900年至1919年， 从1965年到1968年。 大量基于流行病学的数据被 这些人被收集起来，他们一直在不断地 医院监测癌症，因为他们的检查。 通过 1988年9月，这是这5- 一年的建议，预计将有1289癌症 在研究人群中诊断的偶发病例：215例前列腺， 肺癌202例，胃癌190例，结肠癌188例，直肠癌101例， 他人 我们计划在这一队列中研究以下内容：1） 血清尿酸，一种抗氧化剂，与癌症的关联， 2）进一步探讨了血清与肿瘤的关系 胆固醇与结肠癌的关系; 3）膀胱 癌症（基于90例发病病例）与吸烟， 咖啡，酒精，以及膳食维生素A和C的摄入量; 4） 肺功能测量与肺癌风险的关系; 5)身体活动与癌症风险的关联，特别是 结肠癌; 6）流行病学危险因素的识别 在已故受试者中偶然发现的隐匿性前列腺癌 在接受协议尸检的队列中;以及7） 隐匿性甲状腺疾病流行病学危险因素分析 在死者身上偶然发现的癌症 在这两 基于尸检的研究，患有隐匿性癌症的受试者将 与接受过治疗的无隐匿性癌症的受试者相比， 由病理学家进行尸检 除了这七个目标之外，还有三个目标。 从1971年到1975年，6860名受试者（85.7%的男性） 并采集血清样本。 与此 资源，巢式病例对照研究将使用前， 诊断血清，以确定以下内容：8） 血清胡萝卜素和生育酚组分与鳞状细胞癌 （包括口腔癌，下咽癌，食道癌， 喉和肺）;和9）某些血清痕量 元素（铁，锌，铜）与癌症的具体类型。 最后，还对原始受试者的30%系统样本进行了研究。 1970年至1972年被选为重新审查，当时 空腹血浆甘油三酯和脂蛋白组分 测定了 血浆甘油三酯与高、低甘油三酯血症的关系 和极低密度脂蛋白与特定部位的癌症风险 将在2095名男性的子样本中进行研究。

This is a prospective study of 8006 men of Japanese ancestry, born from 1900 to 1919, who were questioned and examined from 1965 to 1968. A wealth of epidemiologic-based data was collected on these men, and they have been under continuous hospital surveillance for cancer since their examination. By September, 1988, which is the proposed renewal date for this 5- year proposal, it is estimated that there will be 1289 cancer incident cases diagnosed in the study population: 215 prostate, 202 lung, 190 stomach, 188 colon and 101 rectal cancers, among others. We plan to study the following with this cohort: 1) the association of serum uric acid, an antioxidant, with cancer by specific type; 2) a further look at the relation of serum cholesterol to colon cancer; 3) the association of urinary bladder cancer (based on 90 incident cases) with cigarette smoking, coffee, alcohol, and the intake of dietary vitamin A and C; 4) the relation of pulmonary function measurements to lung cancer risk; 5) the association of physical activity with cancer risk, especially colon cancer; 6) the identification of epidemiologic risk factors for occult prostate cancer found incidentally in deceased subjects in the cohort who have received protocol autopsies; and 7) the identification of epidemiologic risk factors for occult thyroid cancer found incidentally in deceased subjects. In these two autopsy-based studies, subjects with occult cancer will be compared with subjects without occult cancer who have received protocol autopsies done by the pathologist. In addition to these seven objectives, there are three others. From 1971 to 1975, 6860 subjects (85.7% of the original 8006 men) were re-examined and serum samples were collected. With this resource, nested case-control studies will be done using pre- diagnostic serum to determine the following: 8) the relation of serum carotene and tocopherol fractions to squamous cell cancer (which includes cancer of the mouth, hypopharynx, esophagus, larynx, and lung); and 9) the association of certain serum trace elements (iron, zinc, copper) with cancer by specific type. Finally, a 30% systematic sample of the original subjects was also chosen for re-examination from 1970 to 1972, at which time fasting plasma triglycerides and lipoprotein fractions were measured. The association of plasma triglycerides and high, low and very low density lipoprotein with cancer risk at specific sites will be studied in this sub-sample of 2095 men.