CANCER SERO EPIDEMIOLOGY AMONG THE JAPANESE IN HAWAII

描述：(改编自《调查者摘要》) 确定相关生化标志物的血清流行病学前瞻性研究 在11,132名接受检查的美国日裔受试者中发现常见癌症 在夏威夷。他们未解冻的血清，在诊断前多年获得 将用于这项研究。该提案的重点是 五个特定的癌症部位：前列腺癌、结肠癌、乳腺癌、胃癌和尿路癌 膀胱。将解决八个具体目标：1)确定是否 低水平的血清异黄酮会增加罹患前列腺癌的风险； 看看低血清硒水平是否会增加前列腺癌的风险；3) 确定高胰岛素水平是否会增加患结肠癌的风险 男性患癌症的风险；4)发现低水平的血清异黄酮类化合物是否会增加 女性患乳腺癌的风险；5)确定男性是否携带 幽门螺杆菌Vac-A菌株患胃癌的风险增加； 6)了解幽门螺杆菌血清标志物的存在是否会增加患 男性的总死亡率和特定原因死亡率；7)找出血清中 维生素A和类胡萝卜素与膀胱呈负相关 男性的癌症风险；8)确定低血清硒水平是否 增加男性患膀胱癌的风险。 AIM 4的人口基数由1787名妇女组成，她们出生于1900至1935年 他们在1975-1977年间接受了采访和检查。其余部分的主题 其中有9345名出生于1896年至1935年的男性接受了采访和 从1971年到1976年进行了检查。大量基于流行病学的数据是 收集了这些参与者的信息，他们一直在不断地 自检查以来，医院一直在监测癌症。 本方案将采用两种类型的研究设计：1)前瞻性研究 研究(AIMS 6)；2)嵌套病例对照研究(AIMS其余部分)。它是 估计事件数目如下：376宗 前列腺癌、387例结肠癌、120例乳腺癌、293例胃癌和131例膀胱癌 案子。特定原因死亡病例的数量应至少为870例。 男性中有冠状动脉死亡、1277例癌症死亡和4145例死亡。

DESCRIPTION: (Adapted from the Investigator's Abstract) This is a sero-epidemiologic prospective study to identify biochemical markers related to common cancers occurring among 11,132 American Japanese subjects examined in Hawaii. Their unthawed serum, obtained many years prior to the diagnosis of cancer, will be used in the investigation. The proposal is focused on five specific cancer sites: prostate, colon, breast, stomach and urinary bladder. Eight specific aims will be addressed: 1) to determine whether low serum isoflavonoid levels increase the risk of prostate cancer; 2) to see if low serum selenium levels increase prostate cancer risk; 3) to determine whether high serum insulin level increases the risk of colon cancer risk in men; 4) to find out if low serum isoflavonoid levels increase breast cancer risk in women; 5) to determine whether men carrying the Helicobacter pylori Vac-A strains are at increased risk for stomach cancer; 6) to see if the presence of H. pylori serum markers increase the risk of total and cause-specific mortality in men; 7) to find out if serum levels of vitamin A and carotenoids are inversely associated with urinary bladder cancer risk in men; 8) to determine whether low serum selenium levels increase urinary bladder cancer risk in men. The population base for aim 4 consists of 1787 women, born from 1900 to 1935 who were interviewed and examined from 1975-1977. The subjects for the rest of the aims are 9345 men born from 1896 to 1935, who were interviewed and examined from 1971 to 1976. A wealth of epidemiologic-based data was collected on these participants, and they have been under continuous hospital surveillance for cancer since their examination. Two types of study design will be used in this proposal: 1) prospective study (aim 6); 2) nested case-control study (the rest of the aims). It is estimated that the number of incident cases will be as follows: 376 prostate, 387 colon, 120 breast, 293 stomach, and 131 urinary bladder cancer cases. The number of cause -specific mortality cases should be at least 870 coronary deaths, 1277 cancer deaths and 4145 deaths among the men.