THE ASSOCIATION OF DIET AND OTHER FACTORS WITH GASTRIC CANCER

虽然胃癌的发病率在美国有所下降，是 仍然是世界上癌症死亡的第二大原因。 之甚少 我们知道其致病因素，部分原因是， 研究通常只关注一两个潜在的风险因素。 这项为期5年的基于人群的病例对照研究的主要目的是 是为了检验幽门螺杆菌感染的假设， 胃蛋白酶原I/II比率，高盐或亚硝酸盐摄入，低盐或亚硝酸盐摄入， 特定的水果和蔬菜以及胃癌家族史， 单独地或组合地，鉴定处于这种高风险的受试者。 疾病 预计将对436例病例和436例对照进行访谈， 在研究期间采集血样。 符合条件的案件将 在9家最大的医院进行诊断， 他们的诊断。 一个基于人群的对照将是频率匹配的 按性别、年龄（5岁以内）和种族（高加索人， 中国人、菲律宾人、夏威夷人/半夏威夷人或日本人。 一份包括约250种食物的综合饮食问卷将于 给每个研究参与者。 它将估计通常的 特定食物的饮食摄入以及硝酸盐的摄入， 亚硝酸盐、亚硝胺、钠、维生素C、α-生育酚和β- 胡萝卜素 除了饮食数据外，调查问卷还将包括 以下：癌症家族史，包括胃癌;过去 胃或十二指肠溃疡、胃息肉和胃溃疡病史 手术;吸烟史;使用维生素补充剂。 每个病例的切片将由病理学家进行组织学检查 分型（肠型或弥漫型）。 将进行以下测试 与血液样本：幽门螺杆菌IgG抗体测定，H.幽门 细胞毒素抗体测定、胃蛋白酶原I和II水平以及ABO血液 输入. 数据分析将包括剂量-反应评估 关系，无论是单独或组合，亚硝酸盐摄入量， 盐摄入量、维生素C摄入量、特定果蔬摄入量、H. 幽门螺杆菌抗体水平与胃癌的关系 非条件logistic 将进行回归分析以估计比值比。 这项调查将有助于我们了解的作用， 膳食因素、H.幽门螺杆菌感染和家族史的病因 胃癌 调查结果应提供有用的信息， 这种疾病的初级预防。

Although the incidence of gastric cancer has declined in the U.S., it is still the second leading cause of cancer deaths in the world. Little is known about its causative factors, partly due to the fact that most studies have usually focused on just one or two potential risk factors. The primary objective of this 5-year population-based, case-control study is to test the hypothesis that Helicobacter pylori infection, a low serum pepsinogen I/II ratio, a high salt or nitrite intake, a low intake of specific fruits and vegetables and a family history of gastric cancer, separately or in combination, identifies a subject at high risk for this disease. A total of 436 cases and 436 controls are expected to be interviewed with collection of a blood sample during the study period. Eligible cases will be diagnosed at the 9 largest hospitals with histological confirmation of their diagnosis. One population-based control will be frequency-matched to each case by sex, age (within 5 years) and ethnicity (Caucasian, Chinese, Filipino, Hawaiian/part-Hawaiian or Japanese. A comprehensive dietary questionnaire with about 250 food items will be administered to each study participant. It will estimate the usual dietary intake of specific food items as well as the intake of nitrate, nitrite, nitrosamines, sodium, vitamin C, alpha-tocopherol, and beta- carotene. In addition to the dietary data, the questionnaire will include the following: family history of cancer, including gastric cancer; past medical history of gastric or duodenal ulcer, gastric polyps and gastric surgery; cigarette smoking history; use of vitamin supplements. The slides of each case will be reviewed by a pathologist for histological typing (intestinal or diffuse type). The following tests will be done with the blood sample: Helicobacter pylori IgG antibody assay, H. pylori cytotoxin antibody assay, pepsinogen I and II levels, and ABO blood typing. Analysis of data will consist of an assessment of the dose-response relationships, either separately or in combination, of nitrite intake, salt intake, vitamin C intake, specific fruit and vegetable intake, H. pylori antibody levels to gastric cancer. Unconditional logistic regression analyses will be done to estimate the odds ratios. This investigation will contribute to our understanding of the role of dietary factors, H. pylori infection and family history in the etiology of gastric cancer. The findings should provide useful information towards the primary prevention of this disease.