Exploitation of genomic selection technologies in the UK sheep population

英国绵羊群体基因组选择技术的应用

• 批准号: BB/K012630/1
• 负责人: Nigel Scollan
• 金额: $ 52.38万
• 依托单位: Aberystwyth University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FK012630%2F1
• 关键词: Exploitation; genomic; selection; technologies; UK

'Omics - development of novel tools and techniques to better access, understand and enable the exploitaiton of genomic, transcriptomic, proteomic and metabolomic information. This proposal aims to enable innovations that will enhance the supply of more efficient and productive breeding stock to the UK sheep sector through the development and exploitation of new genomic technologies by a consortium comprising key innovators within the UK lamb supply chain and from other disciplines (e.g. plant genomics). The resulting technology will be capable of application throughout the Industry so that the economic, social, and environmental benefits can be further exploited across the UK sector and will provide important new information that may be applied in other speciesThe proposal aims to yield complex genomic and phenotypic information on a quality and scale that has not been attempted before in UK sheep. This will lead to the use of Genomic Breeding Values (GBVs) which will enable genetic improvement of the more difficult to improve traits that cannot currently be easily, quickly or cheaply measured in vivo. In doing so it fits with the call remit as it:1. Is inspired by the latest developments in genomic technologies following the publication of the sheep genome and development of SNPs capable of identifying new production traits in sheep 2. Will endeavour to use a very large number of measured traits in a large animal population to develop new tools that can be used to apply these technologies so that they can be exploited in commercial sheep populations in the UK for the first time. 3. Will use novel approaches to relate specific haplotype blocks and copy number variations to phenotypic variation and in doing so support the development of future sheep SNP technolgy.4. Will improve the yield and quality of lamb from the same cost base and in doing so support economic growth and environmental sustainability throughout the lamb supply chain5. Will enable Innovis and subsequently the UK sheep industry to utilise genomic selection to safeguard its markets against overseas competition.

组学-开发新的工具和技术，以更好地访问，理解和利用基因组学，转录组学，蛋白质组学和代谢组学信息。该提案旨在通过由英国羊肉供应链内的关键创新者和其他学科（例如植物基因组学）组成的财团开发和利用新的基因组技术，实现创新，以提高英国绵羊部门更有效和生产性的育种库存。由此产生的技术将能够在整个行业中应用，以便经济，社会和环境效益可以在整个英国部门进一步利用，并将提供可能应用于其他物种的重要新信息该提案旨在产生复杂的基因组和表型信息，其质量和规模在英国绵羊中尚未尝试过。这将导致使用基因组育种值（GBV），这将使遗传改良更难以改善的性状，目前不能容易，快速或廉价地在体内测量。在这样做的时候，它符合呼叫汇，因为它：1。灵感来自于基因组技术的最新发展，绵羊基因组的出版和能够识别绵羊新生产性状的SNP的发展。将努力使用大量的测量性状在一个大的动物种群，开发新的工具，可用于应用这些技术，使他们可以在商业绵羊种群在英国首次利用。3.将使用新的方法将特定的单倍型块和拷贝数变异与表型变异联系起来，并在这样做的过程中支持未来绵羊SNP技术的发展.将在相同的成本基础上提高羊肉的产量和质量，从而支持整个羊肉供应链的经济增长和环境可持续性5。将使Innovis和随后的英国绵羊产业能够利用基因组选择来保护其市场免受海外竞争。