Nanosilver antimicrobial resistance in target pathogens

目标病原体中的纳米银抗菌药物耐药性

• 批准号: DP180100474
• 负责人: A/Prof Cindy Gunawan
• 金额: $ 26.1万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-04-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180100474
• 关键词: Nanosilver; antimicrobial; resistance; target; pathogens

This project aims to elucidate the important phenomena of bacterial resistance to antimicrobial nanosilver, currently one of the most developed and commercialised products of nanotechnology. The integrated research approach comprises of concurrent identification of the origins and routes of nanosilver toxicity in bacteria and the arising emergence and mechanisms of bacterial defence to the toxicity. The generated knowledge is to form a base template for novel nanosilver engineering with less tendency for resistance development and to facilitate tracking of resistance and its spread amongst microorganisms. The knowledge has far-reaching implications on the better governance of nanosilver use, including its disposal.

该项目旨在阐明细菌对抗菌纳米银的耐药性的重要现象，纳米银是目前最发达和商业化的纳米技术产品之一。综合研究方法包括同时鉴定细菌中纳米银毒性的起源和途径以及细菌防御毒性的出现和机制。所产生的知识是形成用于新型纳米银工程的基础模板，其具有较少的抗性发展趋势，并有助于追踪抗性及其在微生物中的传播。这些知识对更好地管理纳米银的使用，包括其处置具有深远的影响。