The Molecular Basis of Nanoparticle Resistance in Mixed-Species Biofilm

混合物种生物膜中纳米粒子耐药性的分子基础

• 批准号: DP220101819
• 负责人: A/Prof Cindy Gunawan
• 金额: $ 26.94万
• 依托单位: University of Technology Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-09-13 至 2025-09-12
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220101819
• 关键词: Molecular; Basis; Nanoparticle; Resistance; Mixed

The project aims to understand how the globally significant mixed-species growth of pathogens develop resistance to silver nanoparticle, currently one of the most important alternative antimicrobials to antibiotics. The integrated research is to elucidate, for the first time, the nanoparticle multi-targeting toxicity on mixed-species bacterial community and how, in turn, the bacteria activate their cell-to-cell signalling for a synergistic defence to adapt to the nanoparticle toxicity. The pioneering knowledge is the foundation for technologies targeting the interspecies metabolite cross-talking to overcome the resistance phenomena, ensuring a long-term efficacy of the alternative antimicrobial on the difficult-to-control pathogenic growth.

该项目旨在了解全球重要的病原体混合物种生长如何对银纳米颗粒产生耐药性，银纳米颗粒是目前最重要的抗生素替代抗菌剂之一。这项综合研究首次阐明了纳米颗粒对混合物种细菌群落的多靶向毒性，以及细菌如何反过来激活其细胞间信号传导以进行协同防御以适应纳米颗粒毒性。这些开创性的知识是针对种间代谢物相互作用的技术的基础，以克服耐药性现象，确保替代抗菌剂对难以控制的病原体生长的长期有效性。