Manufacture and applicator technologies for commercialisation of polymeric microneedle arrays

聚合物微针阵列商业化的制造和施用器技术

• 批准号: BB/K020234/1
• 负责人: Ryan Donnelly
• 金额: $ 90.4万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FK020234%2F1
• 关键词: Manufacture; applicator; technologies; commercialisation; polymeric

We have developed a novel type of transdermal patch with tiny needles on its surface that painlessly and without causing bleeding by-pass the skin's stratum corneum barrier. These needles either dissolve quickly, leaving tiny holes in the skin, which will let proteins and peptides enter the body, or swell, turning into a jelly-like material that keeps the holes open and allows continuous delivery. Our technology is unique and could potentially revolutionise delivery of medicines. Interestingly, we have also found that our swellable microneedles can extract fluid from the skin. This permits us to monitor the levels of drugs in a person's blood without actually taking blood samples, meaning that adverse events and complications arising from blood sampling could be prevented, to the benefit of patients Worldwide. In this project, we will focus on moving our microneedle production from laboratory scale to industrial scale and design and validation of a low-cost user friendly applicator.

我们已经开发出一种新型的透皮贴剂，其表面带有微小的针头，可以无痛地绕过皮肤的角质层屏障，不会引起出血。这些针要么迅速溶解，在皮肤上留下小孔，这将使蛋白质和肽进入体内，要么膨胀，变成一种类似海绵的材料，使孔保持开放，并允许连续输送。我们的技术是独一无二的，可能会彻底改变药物的输送。有趣的是，我们还发现我们的可膨胀微针可以从皮肤中提取液体。这使我们能够监测一个人血液中的药物水平，而无需实际采集血液样本，这意味着可以预防血液采样引起的不良事件和并发症，从而使全球患者受益。在这个项目中，我们将专注于将我们的微针生产从实验室规模转移到工业规模，并设计和验证一种低成本的用户友好型涂药器。

项目成果

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

• DOI: 10.1007/s13346-020-00727-2
• 发表时间: 2020-02-26
• 期刊: DRUG DELIVERY AND TRANSLATIONAL RESEARCH
• 影响因子: 5.4
• 作者: Al-Kasasbeh, Rehan;Brady, Aaron J.;Donnelly, Ryan F.
• 通讯作者: Donnelly, Ryan F.

How can microneedles overcome challenges facing transdermal drug delivery?

微针如何克服透皮给药面临的挑战？

• DOI: 10.4155/tde-2017-0028
• 发表时间: 2017
• 期刊: Therapeutic delivery
• 影响因子: 4.2
• 作者: Donnelly RF

In vivo studies investigating biodistribution of nanoparticle-encapsulated rhodamine B delivered via dissolving microneedles.

• DOI: 10.1016/j.jconrel.2017.04.022
• 发表时间: 2017-11-10
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Kennedy J;Larrañeta E;McCrudden MTC;McCrudden CM;Brady AJ;Fallows SJ;McCarthy HO;Kissenpfennig A;Donnelly RF
• 通讯作者: Donnelly RF

A facile system to evaluate in vitro drug release from dissolving microneedle arrays.

• DOI: 10.1016/j.ijpharm.2015.11.038
• 发表时间: 2016-01-30
• 期刊: International journal of pharmaceutics
• 影响因子: 5.8
• 作者: Larrañeta E;Stewart S;Fallows SJ;Birkhäuer LL;McCrudden MT;Woolfson AD;Donnelly RF
• 通讯作者: Donnelly RF

Hydrogel-forming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected.

• DOI: 10.1002/jps.23921
• 发表时间: 2014-05
• 期刊: JOURNAL OF PHARMACEUTICAL SCIENCES
• 影响因子: 3.8
• 作者: Donnelly, Ryan F.;Mooney, Karen;Mccrudden, Maeliosa T. C.;Vicente-Perez, Eva M.;Belaid, Luc;Gonzalez-Vazquez, Patricia;Mcelnay, James C.;Woolfson, A. David
• 通讯作者: Woolfson, A. David