Nanoengineered microneedle arrays for enhanced plasmonic photothermal therapy of basal cell carcinoma.

纳米工程微针阵列用于增强基底细胞癌的等离子体光热疗法。

• 批准号: EP/P034063/1
• 负责人: Ryan Donnelly
• 金额: $ 104.67万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FP034063%2F1
• 关键词: Nanoengineered; microneedle; arrays; enhanced; plasmonic

Basal cell carcinoma (BCC) is the most common cancer in the UK, affecting up to 39% of people at some stage in their lives. BCC is caused by skin exposure to ultraviolet radiation and, therefore, commonly affects the face. BCC is not typically fatal, as it does not metastasise to other parts of the body. However, it is locally destructive and, if not treated effectively, will invade through the skin and underlying tissues resulting in significant disfigurement, pain, ulceration, nerve damage and, potentially, loss of vision for patients with lesions around the eyes. It is estimated that 53,000 new cases are diagnosed in the UK each year. The mean cost to treat a single BCC lesion is currently around £1000. Our ageing population and ever-increasing exposure to ultraviolet radiation suggest that the incidence of BCC will continue to increase, so the estimated cost of management of BCC to the NHS is predicted to rise to around £97 million per year by 2020. Management of BCC by surgical excision can be curative in >95% of cases. However, surgery can cause unsightly scarring and ongoing pain, affecting patients' health-related-quality of life and self-esteem. Alternative treatment options are not particularly effective and are associated with numerous drawbacks.Here, we will investigate a novel treatment based on tiny plastic needles containing microscopic, non-toxic, gold particles. These microneedle arrays will be designed to be inserted by hand into difficult-to-treat deep BCC tumours. Upon illumination with a special type of infrared light, the gold particles will heat up and this heat will diffuse from the tiny needles into the tumour, increasing its temperature enough to kill the cancer cells, but leaving the surrounding normal tissue unharmed. The microneedles containing the gold particles will then be removed intact from the skin, leaving nothing behind and the skin will heal up without scarring.The technology developed here is unique and could potentially revolutionise treatment of the most common type of skin cancer. It offers the opportunity for dramatically improved treatment, with potential benefits for both patients and the NHS. Ultimately, commercialisation of the technology will be the primary route by which UK industry, the NHS and patients will derive benefits. In order to attract potential industrial or venture-funding partners, it is vitally important to demonstrate proof of concept for this technology, which is the over-arching aim of the present proposal.

基底细胞癌(BCC)是英国最常见的癌症，高达39%的人在一生中的某个阶段受到影响。基底细胞癌是由皮肤暴露在紫外线辐射下引起的，因此通常会影响面部。基底细胞癌通常不是致命的，因为它不会转移到身体的其他部位。然而，它是局部破坏性的，如果得不到有效治疗，将通过皮肤和底层组织侵入，导致严重的毁容、疼痛、溃疡、神经损伤，并可能导致眼睛周围病变的患者丧失视力。据估计，英国每年新增确诊病例5.3万例。目前，治疗单个基底细胞癌病变的平均成本约为1000 GB。我们的人口老龄化和不断增加的紫外线辐射暴露表明，基底细胞癌的发病率将继续增加，因此，到2020年，基底细胞癌对国民健康保险制度的估计管理成本将上升到每年约9700万GB。通过手术切除治疗基底细胞癌可以治愈95%的病例。然而，手术可能会造成难看的疤痕和持续的疼痛，影响患者与健康相关的生活质量和自尊。其他的治疗方案并不是特别有效，而且与许多缺点相关。在这里，我们将研究一种基于微小的塑料针头的新型治疗方法，其中含有微小的、无毒的金粒子。这些微针阵列将被设计成手动插入到难以治疗的深层BCC肿瘤中。在一种特殊类型的红外线照射下，金粒子将被加热，这种热量将从微小的针头扩散到肿瘤中，增加其温度，足以杀死癌细胞，但不会损害周围的正常组织。然后，含有黄金颗粒的微针将被完整地从皮肤上移除，不会留下任何东西，皮肤将会愈合而不会留下疤痕。这里开发的技术是独一无二的，可能会彻底改变最常见皮肤癌的治疗方法。它提供了极大地改善治疗的机会，对患者和NHS都有潜在的好处。最终，这项技术的商业化将是英国工业界、英国国民健康保险制度和患者受益的主要途径。为了吸引潜在的工业或风险投资伙伴，至关重要的是证明这项技术的概念，这是本提案的总体目标。

项目成果

A New and Sensitive HPLC-UV Method for Rapid and Simultaneous Quantification of Curcumin and D-Panthenol: Application to In Vitro Release Studies of Wound Dressings.

• DOI: 10.3390/molecules27061759
• 发表时间: 2022-03-08
• 期刊: Molecules (Basel, Switzerland)
• 作者: Anjani QK;Utomo E;Domínguez-Robles J;Detamornrat U;Donnelly RF;Larrañeta E
• 通讯作者: Larrañeta E

Evaluation of the clinical impact of repeat application of hydrogel-forming microneedle array patches

• DOI: 10.1007/s13346-020-00727-2
• 发表时间: 2020-02-26
• 期刊: DRUG DELIVERY AND TRANSLATIONAL RESEARCH
• 影响因子: 5.4
• 作者: Al-Kasasbeh, Rehan;Brady, Aaron J.;Donnelly, Ryan F.
• 通讯作者: Donnelly, Ryan F.

Surfactant-free Synthesis of Spiky Hollow Ag-Au Nanostars with Chemically Exposed Surfaces for Enhanced Catalysis and Single-Particle SERS.

• DOI: 10.1021/jacsau.1c00462
• 发表时间: 2022-01-24
• 期刊: JACS Au
• 影响因子: 8
• 作者: Ye Z;Li C;Celentano M;Lindley M;O'Reilly T;Greer AJ;Huang Y;Hardacre C;Haigh SJ;Xu Y;Bell SEJ
• 通讯作者: Bell SEJ

Coated polymeric needles for rapid and deep intradermal delivery

• DOI: 10.1016/j.ijpx.2020.100048
• 发表时间: 2020-12-01
• 期刊: INTERNATIONAL JOURNAL OF PHARMACEUTICS-X
• 影响因子: 4.7
• 作者: Carcamo-Martinez, Alvaro;Anjani, Qonita Kurnia;Donnelly, Ryan F.
• 通讯作者: Donnelly, Ryan F.