VIRAL MALIGNANT LYMPHOMAGENESIS

淋巴肿大是一个多步骤的过程，在这个过程中淋巴瘤 随着时间的推移，细胞的致瘤性越来越强。在最初 在疾病的各个阶段，生长因子依赖的细胞占主导地位； 进展期的染色体和癌基因 重新安排占上风。具有染色体或染色体的白血病 癌基因重排的预后较差。 那些缺乏基因固定重排的人。因此，它是 最重要的是研究初始的、生长因子依赖的 从而便于合理设计疾病的分期 基因重排发生前的干预方法。 辐射(AN)诱发小鼠T细胞白血病/淋巴瘤 致病因子)最初包括依赖于生长因子， 自分泌细胞。生长因子的性质(创造出来的 淋巴瘤生长因子及其细胞表面受体 (LGF-R)将通过编码基因的分子克隆来研究 他们。编码LGF和LGF-R的分子克隆将 在核酸和蛋白质水平上进行了研究。抗体特异性 将为LGF和LGF-R做好准备。地点(S) LGF/LGF-R阳性细胞首先在接受治疗的小鼠中进化，以及 这些细胞的特性将被研究。《存在》 未治疗小鼠的LGF/LGF-R阳性细胞表型 也将进行研究。 儿童急性T细胞白血病(T-ALL) 似乎涉及依赖LGF的阶段，在该阶段中 与小鼠LGF相似的因子也有牵连。因此，研究 小鼠淋巴瘤的早期生长因子依赖期 也应该加深我们对童年T-ALL的理解。

Lymphomagenesis is a mulitstep process in which the lymphoma cells become increasingly tumorigenic with time. In the initial phases of the disease, growth factor-dependent cells dominate; During the progression phases chromosome and oncogene rearrangements prevail. Leukemias possessing chromsomes or oncogene rearrangements have a poor prognosis compared to those lacking genetically-fixed rearrangements. Thus, it is of upmost importance to study the initial, growth-factor dependent phases of the disease so as to facilitate the design of rational approaches of intervention before gene rearrangementts occur. T leukemia/lymphomas of mice that are induced by radiation (an etiologic agent) initially comprise growth factor-dependent, autocrine cells. The nature of the growth factor (coined Lymphoma Growth Factor, LGF) and its cell surface receptor (LGF-R) will be studied by molecular cloning of genes encoding them. Molecular clones encoding the LGF and LGF-R will be studied on the nucleic acid and protein level. Antibodies specific for the LGF and LGF-R will be prepared. The site(s) at which LGF/LGF-R-positive cells first evolve in treated mice, as well as the characteristics of such cells will be studied. The existance and phenotypes of LGF/LGF-R-positive cells in non-treated mice will also be studied. Childhood Acute Lymphoblastic Leukemia of T cells (T-ALL) also appears to involve an LGF-dependent phase in which a growth factor similar to the murine LGF is implicated. Thus the study of the early, growth factor-dependent phase of murine lymphoma should further our understanding of childhood T-ALL as well.