DIAGNOSTIC RADIOLOGY-IMAGING--CHEMOTHERAPY-BRAIN TUMOR

本提案中概述的动物研究旨在扩大 临床诊断放射学成像（计算机轴向断层扫描-CT和 核磁共振）和介入放射学（动脉 输注化疗），以改善脑肿瘤的治疗。 更 具体而言，本提案中概述的工作旨在使用新的 动物脑肿瘤模型，以定量比较动脉内 (IA)以及静脉内（IV）施用化疗剂BCNU 影响动物肿瘤和非肿瘤组织药物分布和肿瘤 反应（体积变化和动物存活时间）。 结果将 与理论药物建模系统预测的结果相比。 在 此外，全身毒性，相对于药物给药途径和剂量 将监测和比较给药。 该研究还将 研究类固醇和全氟化碳用于 联合IA和IV化疗。 每一个的影响 联合化疗对脑肿瘤药物分布的影响 并且将研究非肿瘤组织和肿瘤反应。 诊断X光， CT和NMR成像将被用来帮助评估 类固醇减少与肿瘤相关的水肿。 这项研究是 特别重要的是，因为人类脑肿瘤的发病率是 结果表明，传统的治疗方法效果不佳。 的 本申请中提出的工作应提供重要信息， 目前缺乏，这应该提高知识的作用， 介入放射学在脑肿瘤治疗中的应用 研究结果 应该有助于开发新的治疗形式，以改善护理， 脑肿瘤患者的治疗。

The animal research outlined in this proposal is directed towards extending clinical Diagnostic Radiology imaging (Computer Axial Tomography-CT and Nuclear Magnetic Resonance-NMR) and Interventional Radiology (arterial infusion chemotherapy) to improve the treatment of brain tumors. More specifically, work outlined in this proposal is intended to use a new animal brain tumor model to quantitatively compare how the intraarterial (IA) and intravenous (IV) administration of the chemotherapeutic agent BCNU affects animal tumor and non-tumor tissue drug distribution and tumor response (volume changes and animal survival times). The results will be compared to those predicted by theoretical drug modeling systems. In addition, systemic toxicity, relative to the route and dose of drug administration will be monitored and compared. The research will also investigate the effects of steroids and perfluorocarbons when used in combination with IA and IV chemotherapy. The effects of each of these combined with chemotherapy treatments on drug distribution in brain tumor and non-tumor tissue and tumor response will be studied. Diagnostic x-ray, CT and NMR imaging will be employed to help evaluate the effects of steroids on reducing edema associated with the tumor. This research is of particular importance since the incidence of human brain tumors is significant and the results of conventional forms of therapy are poor. The work proposed in this application should provide important information that is currently lacking and which should improve knowledge regarding the role of Interventional Radiology in brain tumor therapy. Results of the study should help to develop new forms of therapy to improve the care and management of the brain tumor patient.