DIAGNOSTIC RADIOLOGY-IMAGING--CHEMOTHERAPY-BRAIN TUMOR

这项提案中概述的动物研究旨在扩大 临床诊断放射成像(计算机轴位断层扫描-CT和 核磁共振)和介入放射学(动脉 输液化疗)，以改善脑肿瘤的治疗。更多 具体地说，本提案中概述的工作意在使用新的 动物脑瘤模型的动脉内定量比较 (IA)和静脉(IV)给予化疗药物BCNU 影响动物肿瘤及非肿瘤组织药物分布和肿瘤 反应(体积变化和动物存活时间)。结果将是 与理论药物建模系统预测的结果进行比较。在……里面 此外，全身毒性，与药物的途径和剂量有关 将对行政管理进行监测和比较。这项研究还将 研究类固醇和全氟碳化合物在治疗中的作用 联合IA、IV方案化疗。其中每一项的影响 联合化疗对脑肿瘤药物分布的影响 并对非肿瘤组织和肿瘤反应进行研究。诊断x光， CT和核磁共振成像将被用来帮助评估 类固醇对减轻肿瘤相关的浮肿的作用。这项研究是 尤其重要，因为人类脑瘤的发病率是 传统的治疗方式效果不佳，效果不佳。这个 本申请中提出的工作应提供以下重要信息 目前是缺乏的，这应该会提高关于角色的知识 介入放射学在脑肿瘤治疗中的应用。研究结果 应有助于开发新的治疗形式，以改善护理和 脑肿瘤患者的管理。

The animal research outlined in this proposal is directed towards extending clinical Diagnostic Radiology imaging (Computer Axial Tomography-CT and Nuclear Magnetic Resonance-NMR) and Interventional Radiology (arterial infusion chemotherapy) to improve the treatment of brain tumors. More specifically, work outlined in this proposal is intended to use a new animal brain tumor model to quantitatively compare how the intraarterial (IA) and intravenous (IV) administration of the chemotherapeutic agent BCNU affects animal tumor and non-tumor tissue drug distribution and tumor response (volume changes and animal survival times). The results will be compared to those predicted by theoretical drug modeling systems. In addition, systemic toxicity, relative to the route and dose of drug administration will be monitored and compared. The research will also investigate the effects of steroids and perfluorocarbons when used in combination with IA and IV chemotherapy. The effects of each of these combined with chemotherapy treatments on drug distribution in brain tumor and non-tumor tissue and tumor response will be studied. Diagnostic x-ray, CT and NMR imaging will be employed to help evaluate the effects of steroids on reducing edema associated with the tumor. This research is of particular importance since the incidence of human brain tumors is significant and the results of conventional forms of therapy are poor. The work proposed in this application should provide important information that is currently lacking and which should improve knowledge regarding the role of Interventional Radiology in brain tumor therapy. Results of the study should help to develop new forms of therapy to improve the care and management of the brain tumor patient.