TRANSLUMINAL ANGIOPLASTY-CONVENITAL HEART DISEASE

这项研究的长期目标是发展干预性 先天性心肺疾病的放射治疗方法 疾病，并调查功能和形态的后遗症 从他们的使用中。动物实验的目的是：(1)评估 慢性左、右室机械电事件 并评估这些异常的程度 影响对非手术瓣膜成形术的反应； (2)拓展血管内技术的临床应用潜力 以先天性心脏病和儿科疾病为重点的支架 心肺应用；以及，(3)扩大应用 血管成形术气囊接近房间隔造口术。对于 第一个工作区，左、右肥大的狗 脑室将被用来评估急性心肌梗死的关系 通过主动脉瓣阻断改变机械负荷。单相 动作电位时程、后除极与心室 异位手术将受到监控。此外，左、右室 将为以下对象建立力-间隔关系 心脏肥大。在第二个项目中，血管内支架 将在猪身上进行评估，以期在 肺、腔静脉和主动脉血管。扩张的能力 将对支架节段进行评估。此外，支架将被 评价为维持导管通畅的一种手段 动脉粥样硬化。在最后一个项目中，定径的应用 血管成形术球囊扩张手术将用于房间隔造口术 在新生的羔羊身上进行评估，并与拉什金羊进行比较 技术。所有的项目都应该提高我们的知识水平 关于非手术经导管的应用 治疗先天性心肺疾病的干预措施。这个 拟议的研究是先前工作的自然延伸 实验室在开发和评估新的经导管治疗方面所做的工作 心脏介入手术。

The long term goal of the research is to develop interventional radiological procedures to treat congenital cardiopulmonary disease, and to investigate functional and morphological sequelae from their use. Animal studies are designed to: (1) assess mechanoelectrical events of chronic left and right ventricular hypertrophy and to evaluate the extent to which these abnormalities influence the response to non-surgical valvuloplasty procedures; (2) to extend the potential clinical applications of intravascular stents with an emphasis on congenital cardiac disease and pediatric cardiopulmonary applications; and, (3) to extend the applications of angioplasty balloon approaches to atrial septostomy. For the first area of work, dogs with hypertrophied left and right ventricles will be used to evaluate the relationship between acute altered mechanical loading via aortic valve occlusion. Monophasic action potential duration, after-depolarizations, and ventricular ectopy will be monitored. In addition, left and right ventricular force-interval relationships will be established for the hypertrophied heart. In the second project, intravascular stents will be evaluated in pigs for their potential clinical use in the pulmonary, vena caval, and aortic vessels. The ability to dilate stented segments will be evaluated. In addition, stents will be evaluated as a means of maintaining patency of the ductus arteriosus. In the last project, the application of fixed diameter angioplasty balloon dilataion procedures for atrial septostomy will be evaluated in newborn lambs and compared to the Rashkind technique. All of the projects should improve our knowledge regarding the application of nonsurgical transcatheter interventions to treat congenital cardiopulmonary disease. The proposed research is a natural extension of previous work this laboratory has done in developing and evaluating new transcatheter cardiac interventional procedures.