TRANSLUMINAL ANGIOPLASTY-CONVENITAL HEART DISEASE

腔内血管成形术-先天性心脏病

• 批准号: 3347483
• 负责人: JAMES H ANDERSON
• 金额: $ 16.9万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1992-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3347483
• 关键词: aortic valve stenosis; arrhythmia; artery stenosis; cardiopulmonary disease; child (0-11); congenital cardiovascular shunt; congenital heart septum defect; disease /disorder model; dogs; electrocardiography; heart function; hemodynamics; intraluminal angioplasty; sheep; swine

The long term goal of the research is to develop interventional radiological procedures to treat congenital cardiopulmonary disease, and to investigate functional and morphological sequelae from their use. Animal studies are designed to: (1) assess mechanoelectrical events of chronic left and right ventricular hypertrophy and to evaluate the extent to which these abnormalities influence the response to non-surgical valvuloplasty procedures; (2) to extend the potential clinical applications of intravascular stents with an emphasis on congenital cardiac disease and pediatric cardiopulmonary applications; and, (3) to extend the applications of angioplasty balloon approaches to atrial septostomy. For the first area of work, dogs with hypertrophied left and right ventricles will be used to evaluate the relationship between acute altered mechanical loading via aortic valve occlusion. Monophasic action potential duration, after-depolarizations, and ventricular ectopy will be monitored. In addition, left and right ventricular force-interval relationships will be established for the hypertrophied heart. In the second project, intravascular stents will be evaluated in pigs for their potential clinical use in the pulmonary, vena caval, and aortic vessels. The ability to dilate stented segments will be evaluated. In addition, stents will be evaluated as a means of maintaining patency of the ductus arteriosus. In the last project, the application of fixed diameter angioplasty balloon dilataion procedures for atrial septostomy will be evaluated in newborn lambs and compared to the Rashkind technique. All of the projects should improve our knowledge regarding the application of nonsurgical transcatheter interventions to treat congenital cardiopulmonary disease. The proposed research is a natural extension of previous work this laboratory has done in developing and evaluating new transcatheter cardiac interventional procedures.

本研究的长期目标是发展干预性 先天性心肺损伤的放射学治疗 疾病，并调查功能和形态后遗症 从他们的使用。 动物研究旨在：（1）评估 慢性左、右心室机械电事件 并评估这些异常的程度 影响对非外科瓣膜成形术的反应; (2)以扩展血管内注射的潜在临床应用， 支架，重点是先天性心脏病和儿科 心肺应用;以及（3）扩展应用 球囊血管成形术进入房间隔造口术。 为 工作的第一个领域，狗与肥大的左，右 心室将用于评价急性 通过主动脉瓣闭塞改变机械负荷。 单相 动作电位时程、后除极和心室肌 将监测异位。 此外，左心室和右心室 将建立力-间隔关系， 心脏肥大 在第二个项目中， 将在猪中评价其潜在的临床用途， 肺、腔静脉和主动脉血管。 扩张的能力 将对植入支架的节段进行评价。 此外，支架将 评价为保持导管通畅的一种方法 动脉 在最后一个项目中， 房间隔造口术的血管成形术球囊扩张术将 在新生羔羊中进行评价，并与Rashkind进行比较 法 所有的项目都应该提高我们的知识 关于非手术经导管 先天性心肺疾病的治疗。 的 拟议的研究是以前工作的自然延伸， 实验室在开发和评估新的经导管 心脏介入手术。

项目成果

Palmaz stent in the treatment of central venous stenosis: safety and efficacy of redilation.

Palmaz 支架治疗中心静脉狭窄：再扩张的安全性和有效性。

• DOI: 10.1148/radiology.190.2.8284384
• 发表时间: 1994
• 期刊: Radiology
• 影响因子: 19.7
• 作者: Trerotola,SO;Lund,GB;Samphilipo,MA;Magee,CA;Newman,JS;Olson,JL;Anderson,JH;OstermanJr,FA
• 通讯作者: OstermanJr,FA

Repeat dilation of Palmaz stents in pulmonary arteries: study of safety and effectiveness in a growing animal model.

肺动脉 Palmaz 支架的重复扩张：生长动物模型中的安全性和有效性研究。

• DOI: 10.1016/s1051-0443(94)71520-7
• 发表时间: 1994
• 期刊: Journal of vascular and interventional radiology : JVIR
• 作者: Trerotola,SO;Lund,GB;Newman,J;Olson,JL;Widlus,DM;Anderson,JH;Mitchell,SE;OstermanJr,FA
• 通讯作者: OstermanJr,FA

Atrial septostomy: stationary angioplasty balloon technique--experimental work and preliminary clinical applications.

房间隔造口术：固定血管成形球囊技术——实验工作和初步临床应用。

• DOI: 10.1007/bf00796998
• 发表时间: 1994
• 期刊: Pediatric cardiology
• 影响因子: 1.6
• 作者: Mitchell,SE;Anderson,JH;Swindle,MM;Strandberg,JD;Kan,J
• 通讯作者: Kan,J