How do MACPF/CDC proteins punch giant holes in lipid membranes?

MACPF/CDC 蛋白如何在脂质膜上打出巨大的孔？

• 批准号: DP180100040
• 负责人: A/Prof Michelle Dunstone
• 金额: $ 29.11万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-06-04 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180100040
• 关键词: How; do; MACPF; CDC; proteins

This project aims to study the Membrane Attack Complex (MAC)/Perforin-like/Cholesterol Dependent Cytolysins (MACPF/CDC) family which form unusually large holes in membranes. This project aims to define the exact molecular shape of a monomer in comparison with the exact molecular shape of the pore of the MACPF/CDC family. This project will also provide new information about the intermediate steps in pore formation. This will have major benefits to agribusiness and nanotechnology applications.

本项目旨在研究在膜上形成异常大孔的膜攻击复合物(MAC)/穿孔素样/胆固醇依赖性细胞溶解素（MACPF/CDC）家族。该项目旨在定义单体的确切分子形状，与MACPF/CDC家族的孔的确切分子形状进行比较。该项目还将提供有关孔隙形成中间步骤的新信息。这将对农业综合企业和纳米技术的应用产生重大好处。