BREAST CANCER BRAIN METASTASIS

脑转移瘤是一种比较常见的肿瘤 然而，在一些常见的系统性癌症中， 尽管最近的治疗方法， 预付款。 本项目旨在检查转移性脑 人和大鼠来源的乳腺癌肿瘤， 从生物学、病理学和生化学角度来看， 特性. 最初的重点是开发相关的动物 使用13762 NF乳腺癌的大鼠转移性脑肿瘤模型 腺癌 初步研究表明， 通过反复的筛选， 肿瘤细胞进入颈动脉的连续循环 动脉，收获脑肿瘤结节和体外生长， 组织培养 一个主要的重点将是比较老鼠的大脑 人乳腺癌脑转移瘤细胞 病变，也适用于适当的原发性肿瘤和其他 其他器官的远处转移。 各种可能的路线 肿瘤细胞在脑中的转移性扩散也将是 研究了 各种转移性脑肿瘤细胞 检查其生物学特性、病理学， 卡里奥特莱斯 此外，肿瘤的细胞表面成分 将检查细胞以确定是否表达 糖蛋白、蛋白质、蛋白聚糖或糖脂相关 他们的大脑殖民能力。 多细胞表面 已经证明，这两种成分都可以表达 人和大鼠乳腺癌细胞及其改变 表达水平可反映肿瘤细胞的转移能力。 这些结果的推广可能会使我们对 转移性脑肿瘤植入、生长和定植 以及新的治疗方法。

Tumor metastasis to the brain is a relatively frequent occurance in a number of common systemic cancers, however, the prognosis of afflicted patients remains grim despite recent therapeutic advances. This project proposes to examine metastatic brain tumors from mammary carcinoma of human and rat origin, in terms of their biological, pathological, and biochemical properties. An initial focus is to develop a relevant animal metastatic brain tumor model in rat using the 13762NF mammary adenocarcinoma. Preliminary studies have suggested that brain colonizing tumor cell variants are being selected by repeated sequential cycles of inoculating tumor cells into the carotid artery, harvesting the brain tumor nodules and in vitro growth in tissue culture. A major emphasis will be to compare the rat brain metastatic tumor cells to human mammary carcinoma brain lesions and also to the appropriate primary tumor and other distant metastases in other organs. The various possible routes of metastatic spread of the tumor cells in the brain will also be investigated. The various metastatic brain tumor cells will be examined for their biological properties, pathologies, and kariotypes. Furthermore, the cell surface components of tumor cells will be examined to determine if the expression of glycoproteins, proteins, proteoglycans, or glycolipids correlates with their brain colonizing ability. Several cell surface components have been demonstrated to be expressed by both human and rat breast carcinoma cells, and their altered expression may reflect the tumor cells metastatic capabilities. Extension of these results may lead us to new understanding of metastatic brain tumor implantation, growth, and colonization and to new approaches in therapy.