Experimental Analysis of Intracerebral Immunosurveillance Mechanism and Its Clinical Application to Management of Brain Neoplasms

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1. Basic Research :(1) It was suggested that major histocompatibility complex (MHC, 14-2 in mice)-positive tumor cells grafted into the brain may be rejected by cytotoxic T lymphocytes (CTL) in an MHC-dependent manner, whereas MHC-negative tumor cells can escape from CTL-mediated immunosurveillance and grow progressively in the brain, due to absence of intracerebral natural resistance mediated by natural killer (NK) cells.(2) We demonstrated that interferon- beta had no apparent effect on intracellular calcium mobilization of the murine malignant astrocytoma cells, while there was an inhibitory action of the cytokine on the tumor cell proliferation.2. Clinical Research :(1)We devised an operative modality with ultrasound and neuroendoscope-assisted microsurgical techniques based upon the concept of minimally invasive neurosurgery for patients with brain neoplasms to enhance the postoperative quality of life.(2) We examined the long-term outcome and quality of life in the pediatric and geriatric patients with brain neoplasms, surviving more than 5 years after multidisciplinary treatments. With special reference to complication, more attention should be exercised to the brain/spinal cord injuries following radiotherapy of pediatricand geriatric patients.