Analysis of relationship between immunosurveillance and tumorigenesis in the brain and new approach to treatment of brain neoplasms

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1. BASIC RESEARCH :(1) Experimental analysis of relationship between proto-oncogene and histocompatibility complex antigen gene expressions during brain tumor progression.(2) Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression.(3) Role of nitric oxide and tumor necrosis factor-alpha produced by activated macrophages in cytotoxic activity on malignant glioma cells.(4) Effects of nitric oxide and tumor necrosis factor-alpha on electrophysiological action in cultured neuronal cell line.2. CLINICAL RESEARCH :(1) Clinical significance of intraoperative monitoring method with endoscopy and Doppler ultrasound techniques for stereotactic surgery and microsurgery.(2) Pharmacokinetic study on concentration of anti-cancer agents in intracranical tumor cavity after intravenous or intraarterial injection in patients with malignant brain tumors.(3) Clinical significance of SPECT in differentiating diagnosis and evaluating predicting prognosis of a variety of brain neoplasms.