Small molecule inhibitors for bovine respiratory syncytial virus

牛呼吸道合胞病毒小分子抑制剂

• 批准号: BB/L024438/1
• 负责人: Andrew Easton
• 金额: $ 24.81万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FL024438%2F1
• 关键词: Small; molecule; inhibitors; bovine; respiratory

Infection of cattle with bovine respiratory syncytial virus is a worldwide problem and results in losses of more than £150 million for the UK farming industry alone. We have shown that BRSV and related viruses express an essential protein, M2-2, by using a novel mechanism that relies on the action of a protein, DDX3 that is present in the cells that the viruses infect. If the virus M2-2 protein is not made in sufficient amounts the virus cannot grow effectively. We have identified a number of inhibitors that interfere with the action of the DDX3 protein and as a result prevent production of the M2-2 protein. This treatment prevents the growth of BRSV and its related viruses. We intend to develop these inhibitors as potential drugs to combat the virus.

牛呼吸道合胞病毒感染是一个世界性的问题，仅英国农业就损失超过1.5亿英镑。我们已经证明，BRSV和相关病毒通过使用一种新型机制表达一种必需蛋白质M2-2，该机制依赖于病毒感染细胞中存在的蛋白质DDX 3的作用。如果病毒M2-2蛋白没有足够的量，病毒就不能有效地生长。我们已经鉴定了许多干扰DDX 3蛋白作用的抑制剂，从而阻止M2-2蛋白的产生。这种处理可防止BRSV及其相关病毒的生长。我们打算开发这些抑制剂作为对抗病毒的潜在药物。