Small molecule inhibitors for bovine respiratory syncytial virus

牛呼吸道合胞病毒感染是一个世界性的问题，仅英国农业就损失超过1.5亿英镑。我们已经证明，BRSV和相关病毒通过使用依赖于病毒感染细胞中存在的蛋白DDX 3的作用的新机制表达必需蛋白M2-2。如果病毒M2-2蛋白没有以足够的量产生，则病毒不能有效地生长。我们已经鉴定了许多干扰DDX 3蛋白作用的抑制剂，从而阻止M2-2蛋白的产生。这种处理可防止BRSV及其相关病毒的生长。我们打算开发这些抑制剂作为对抗病毒的潜在药物。

Infection of cattle with bovine respiratory syncytial virus is a worldwide problem and results in losses of more than £150 million for the UK farming industry alone. We have shown that BRSV and related viruses express an essential protein, M2-2, by using a novel mechanism that relies on the action of a protein, DDX3 that is present in the cells that the viruses infect. If the virus M2-2 protein is not made in sufficient amounts the virus cannot grow effectively. We have identified a number of inhibitors that interfere with the action of the DDX3 protein and as a result prevent production of the M2-2 protein. This treatment prevents the growth of BRSV and its related viruses. We intend to develop these inhibitors as potential drugs to combat the virus.