MARIJUANA SMOKING TYPOGRAPHY AND DOSE REGULATION

吸食大麻的版式和剂量规定

• 批准号: 3207953
• 负责人: Reese T. Jones
• 金额: $ 11.56万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-05-01 至 1987-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3207953
• 关键词: adolescence (12-20); adult human (21+); blood chemistry; cannabinoids; carboxyhemoglobin; dosage; drug tolerance; experience; gender difference; human subject; pharmacokinetics; psychopharmacology; pulmonary respiration; respiratory airflow measurement; respiratory airway volume

We will determine the extent and the means by which people regulate tetrahydrocannabinol (THC) and other substances absorbed during marijuana smoking. Comparisons between adolescent and adult marijuana smokers, frequent and infrequent users, males and females, those who also use tobacco and nontobacco users will demonstrate the techniques, the limits and the magnitude of dose regulation while smoking marijuana of various potency. Reliable measurement techniques already developed will be applied to the cannabis dosimetry research. Puffing and inhaling patterns, including puff volume measured by flow meter techniques and inhalation volume measured by inductance pneumography, will provide a noninvasive and precise protile of how each cigarette is smoked on a puff by puff basis. Cardiovascular, autonomic, and subjective effects and plasma THC, 11-hydroxy THC, 11-nor-9-carboxy THC and carboxyhemolobin measures will allow determination of relationships between smoking patterns, resulting blood levels and effects. Propranolol induced beta adrenergic blockade and resulting changes in smoking behavior will examine the importance of autonomic system feedback in dose regulation. The health significance of a smokers' dose control is only recently being appreciated by some researchers in tobacco studies. It may be of similar importance to marijuana smokers. Several disciplines, including psychopharmacology, psychophysiology, respiratory physiology, pharmacokinetics and behavioral medicine, are involved. The studies have direct public health implications since, as with any drug, dose is likely to be related to both acute and long term consequences. The relationships between marijuana potency and resulting amounts of material absorbed have been little studied. Only incomplete measures of smoking behavior have been previously used in marijuana research. The detailed examination of marijuana smoking behavior in adolescent smokers may enhance prevention strategies.

我们将决定人们监管的程度和手段 四氢大麻酚（THC）和其他物质吸收大麻 smoking. 青少年和成年大麻吸食者之间的比较， 经常和不经常使用者，男性和女性， 烟草和非烟草使用者将展示这些技术， 以及吸食大麻时的剂量调节幅度 力量 已经开发的可靠测量技术将得到应用 大麻剂量测定研究的联系 吸气吸气， 包括通过流量计技术测量的抽吸体积和吸入 通过电感呼吸描记术测量的体积，将提供一种非侵入性的， 每支香烟是如何一口一口地吸的精确原理。 心血管、自主神经和主观效应以及血浆THC， 11-羟基THC、11-去甲-9-羧基THC和羧基血红蛋白测量将 允许确定吸烟模式之间的关系， 血液水平和影响。 普萘洛尔诱导β肾上腺素能阻滞， 吸烟行为的变化将研究以下方面的重要性： 剂量调节中的自主系统反馈。 吸烟者剂量控制的健康意义直到最近才被发现。 一些烟草研究人员对此表示赞赏。 它可能是类似的 大麻吸食者的重要性。 多个学科，包括 精神药理学，精神生理学，呼吸生理学， 药代动力学和行为医学。 这些研究 直接的公共卫生影响，因为与任何药物一样， 与急性和长期后果有关。 的关系 大麻的效力和所吸收的物质之间的关系 很少被研究。 只有不完整的吸烟行为的措施， 以前用于大麻研究。 详细检查 青少年吸烟者的大麻吸烟行为可能会加强预防 战略布局