HYPERTHERMIA AND BRACHYTHERAPY IN BRAIN TUMOR TREATMENT

脑肿瘤治疗中的热疗和近距离治疗

• 批准号: 3184097
• 负责人: DAVID ROBERTS
• 金额: $ 26.29万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3184097
• 关键词: brain neoplasms; central nervous system neoplasms; combination cancer therapy; disease /disorder model; glioblastoma multiforme; human subject; human therapy evaluation; immunochemistry; ionizing radiation; microwave radiation; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; nervous system disorder diagnosis; radiation therapy dosage

Glioblastomas are the most common form of brain tumors, but despite aggressive treatment protocols involving surgery, radiation therapy, and chemotherapy, the mean life time of these patients after diagnosis is 10 months. The long term objective is to investigate the efficacy of interstitial hyperthermia and radiation therapy as a treatment for this type of tumor. Interstitial hyperthermia involves implanting a set of 2 mm catheters in the tumor and then inserting a set of 1 mm microwave antennas into each catheter, along with a thermometry probe. The electromagnetic energy radiated from these antennas heats the tumor volume to the temperature range of 43-50 degrees C. The specific objectives of this research are to 1) continue a phase I clinical trial for the treatment of glioblastoma multiforme (Grade III and IV) in humans, 2) develop 3-dimensional computer-based thermal and radiation treatment planning models, 3) investigate the phenomenon of thermotolerance in normal and tumor tissue, 4) assess long term toxicity of combined heat and radiation in normal brain, 5) study time/temperature dose escalation effects in normal brain, 6) develop a new 2450 MHz interstitial microwave system for clinical and animal studies, and 7) measure the power deposition and thermal dosmetry for new antenna designs. The phase I clinical trial will study the efficacy of treatment of brain tumors using an interstitial microwave antenna array hyperthermia system and brachytherapy. The ability of this system to effectively heat brain tumors will be evaluated as well as the effects of increasing the heated region around the CT defined tumor margin. Fundamental studies will be conducted on questions of thermotolerance, both in normal dog brain and in an avian sarcoma virally induced tumor model. This information could lead to a better treatment protocol for the clinical trials. Thermotolerance will be assessed by neurohistological and heat shock protein analysis. The long term toxicity of combined heat and radiation will be studied for hyperthermia applied with the interstitial system and with low dose irradiation using iridium-192 seeds, again using a dog model. Various heat/radiation combinations will be assessed, i.e. heat-radiation-heat, heat-radiation, radiation-heat, and heat-radiation-heat-radiation. The time/temperature escalation study will be performed using a 915 MHz spiral surface applicator in normal dog brain and the analysis will be based on histological and neuroradiological evaluation 7 days after treatment.

胶质母细胞瘤是最常见的脑肿瘤，但尽管如此， 积极的治疗方案，包括手术，放射治疗， 这些患者诊断后的平均生存时间为10 个月 长期目标是研究 间质热疗和放射治疗作为治疗方法 肿瘤的类型 间质热疗涉及植入一套2毫米 导管在肿瘤，然后插入一组1毫米的微波天线 沿着温度测量探针进入每个导管。 电磁 从这些天线辐射的能量将肿瘤体积加热到 温度范围为43-50摄氏度。 这一具体目标 研究将：1）继续进行I期临床试验， 多形性胶质母细胞瘤（III级和IV级），2）发展 3-三维计算机热辐射治疗计划 模型，3）研究正常和 肿瘤组织，4）评估联合热辐射的长期毒性 在正常脑中，5）研究时间/温度剂量递增效应， 6）开发一种新的2450 MHz组织间微波系统， 临床和动物研究，以及7）测量功率沉积， 用于新天线设计的热剂量学。 I期临床试验将 研究脑肿瘤的治疗效果， 微波天线阵热疗系统和近距离放射治疗。 的能力 该系统有效加热脑肿瘤的能力也将得到评估 由于增加CT定义的肿瘤周围的加热区域的影响， 裕度 将对以下问题进行基础研究 耐热性，无论是在正常狗的大脑和禽肉瘤病毒 诱导肿瘤模型 这些信息可能会导致更好的治疗 临床试验方案 耐热性将通过以下方式进行评估： 神经组织学和热休克蛋白分析。 长期毒性 将研究联合加热和辐射的热疗应用 使用间隙系统和低剂量照射， 铱-192种子，同样使用狗模型。 各种热/辐射 将评估组合，即热辐射热，热辐射， 辐射热和热辐射热辐射。 的时间/温度 将使用915 MHz螺旋表面进行递增研究 施加器在正常的狗脑和分析将基于 治疗后7天进行组织学和神经放射学评价。