HYPERTHERMIA AND BRACHYTHERAPY IN BRAIN TUMOR TREATMENT

脑肿瘤治疗中的热疗和近距离治疗

• 批准号: 3184103
• 负责人: DAVID ROBERTS
• 金额: $ 27.26万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3184103
• 关键词: brain neoplasms; central nervous system neoplasms; combination cancer therapy; disease /disorder model; dogs; glioblastoma multiforme; human subject; human therapy evaluation; immunochemistry; ionizing radiation; microwave radiation; neoplasm /cancer radiation therapy; neoplasm /cancer thermotherapy; nervous system disorder diagnosis; radiation therapy dosage

Glioblastomas are the most common form of brain tumors, but despite aggressive treatment protocols involving surgery, radiation therapy, and chemotherapy, the mean life time of these patients after diagnosis is 10 months. The long term objective is to investigate the efficacy of interstitial hyperthermia and radiation therapy as a treatment for this type of tumor. Interstitial hyperthermia involves implanting a set of 2 mm catheters in the tumor and then inserting a set of 1 mm microwave antennas into each catheter, along with a thermometry probe. The electromagnetic energy radiated from these antennas heats the tumor volume to the temperature range of 43-50 degrees C. The specific objectives of this research are to 1) continue a phase I clinical trial for the treatment of glioblastoma multiforme (Grade III and IV) in humans, 2) develop 3-dimensional computer-based thermal and radiation treatment planning models, 3) investigate the phenomenon of thermotolerance in normal and tumor tissue, 4) assess long term toxicity of combined heat and radiation in normal brain, 5) study time/temperature dose escalation effects in normal brain, 6) develop a new 2450 MHz interstitial microwave system for clinical and animal studies, and 7) measure the power deposition and thermal dosmetry for new antenna designs. The phase I clinical trial will study the efficacy of treatment of brain tumors using an interstitial microwave antenna array hyperthermia system and brachytherapy. The ability of this system to effectively heat brain tumors will be evaluated as well as the effects of increasing the heated region around the CT defined tumor margin. Fundamental studies will be conducted on questions of thermotolerance, both in normal dog brain and in an avian sarcoma virally induced tumor model. This information could lead to a better treatment protocol for the clinical trials. Thermotolerance will be assessed by neurohistological and heat shock protein analysis. The long term toxicity of combined heat and radiation will be studied for hyperthermia applied with the interstitial system and with low dose irradiation using iridium-192 seeds, again using a dog model. Various heat/radiation combinations will be assessed, i.e. heat-radiation-heat, heat-radiation, radiation-heat, and heat-radiation-heat-radiation. The time/temperature escalation study will be performed using a 915 MHz spiral surface applicator in normal dog brain and the analysis will be based on histological and neuroradiological evaluation 7 days after treatment.

胶质母细胞瘤是最常见的脑肿瘤形式，但尽管 积极的治疗方案包括手术、放射治疗和 化疗，这些患者确诊后的平均寿命为10年。 月份。长期目标是研究 间质热疗和放射治疗作为一种治疗方法 肿瘤的类型。间质热疗包括植入一组2 mm的 然后在肿瘤内插入一套1毫米的微波天线 插入每根导尿管，还有一个测温探头。电磁场 从这些天线发出的能量将肿瘤体积加热到 温度范围43-50摄氏度。这个项目的具体目标是 研究将1)继续进行治疗以下疾病的I期临床试验 人类多形性胶质母细胞瘤(III级和IV级)，2)发生 基于计算机的三维热疗和放射治疗计划 模型，3)研究正常和正常大鼠的耐热现象 肿瘤组织，4)评估热和辐射联合的长期毒性 在正常大脑中，5)研究时间/温度剂量递增效应 正常大脑，6)开发一种新的2450 MHz间质微波系统 临床和动物研究，以及7)测量能量沉积和 用于新天线设计的热剂量计。I期临床试验将 间质内注射治疗脑肿瘤的疗效研究 微波天线阵热疗系统与近距离放射治疗。一种能力 该系统是否能有效加热脑瘤也将得到评估 由于CT定义的肿瘤周围加热区域增加的影响 保证金。将对以下问题进行基础性研究 正常狗脑和禽肉瘤病毒的耐热性 诱导肿瘤模型。这一信息可能导致更好的治疗方法 临床试验的方案。耐热性将通过以下方式评估 神经组织学和热休克蛋白分析。长期毒性 将研究热疗和辐射的联合应用 对于间质系统和低剂量照射，使用 Ir-192种子，同样使用了狗的模型。各种热/辐射 将评估组合，即热-辐射-热，热-辐射， 辐射-热，和热-辐射-热-辐射。时间/温度 升级研究将使用915 MHz螺旋面进行 在正常狗脑中的涂抹器和分析将基于 治疗7d后进行组织学和神经放射学评价。