Homeostatic maintenance of the auditory system and its relation to age-dependent hearing loss: A Drosophila model organ study
听觉系统的稳态维持及其与年龄依赖性听力损失的关系:果蝇模型器官研究
基本信息
- 批准号:BB/M008533/1
- 负责人:
- 金额:$ 91.22万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2015
- 资助国家:英国
- 起止时间:2015 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In the UK, some 70% of people over 70 suffer from decline of hearing. Yet, we have acquiesced into this age-related decay of our senses almost as tacitly as we take their faultless operation for granted for most of our lives. Scientifically, both of these phenomena are equally remarkable. Our eyes and ears are parts of the living world and as such they are in constant need of metabolic energy and permanently exposed to countless environmental challenges. In contrast to a granite rock, a biological system that retains constant properties over periods of days, months, or even years, needs an explanation. If then at some point, and without any obvious external cause, system performance eventually declines, a second explanation is required. This research project will study both of these phenomena and test the hypothesis that they are mechanistically interlinked. In other words, what are the cellular mechanisms that maintain our sense of hearing and how do these mechanisms deteriorate over time? Using the antennal ears of the fruit fly Drosophila melanogaster as a model sensory organ, we will (i) dissect the molecular network that maintains sensitive hearing throughout the fly's life course and (ii) study how this maintenance, or homeostasis, changes during ageing. We will specifically test the hypothesis that the same molecular networks that direct the construction of the ear in the growing fly (about which we already know quite a lot) also contribute to its homeostatic control during adult life (about which we know very little). Importantly, the molecular networks of ear construction are known to have much in common between flies and humans, and we expect our research will provide a relevant model to understand decline of hearing in humans.
在英国,70岁以上的老人中有70%的人听力下降。然而,我们已经默许了这种与年龄有关的感官衰退,就像我们认为在我们生命的大部分时间里,感官的完美运作是理所当然的一样。从科学上讲,这两种现象同样引人注目。我们的眼睛和耳朵是生命世界的一部分,因此它们不断需要代谢能量,并永久地暴露在无数的环境挑战中。与花岗岩不同,生物系统在几天、几个月甚至几年的时间里保持不变的特性需要解释。如果在某个时刻,并且没有任何明显的外部原因,系统性能最终下降,则需要第二个解释。这个研究项目将研究这两种现象,并检验它们之间存在机械联系的假设。换句话说,维持我们听觉的细胞机制是什么,这些机制是如何随着时间的推移而恶化的?使用果蝇的触角耳作为模型感觉器官,我们将(i)剖析在果蝇整个生命过程中维持敏感听觉的分子网络,(ii)研究这种维持或体内平衡如何在衰老过程中发生变化。我们将专门测试这样一种假设,即在苍蝇生长过程中指导耳朵构造的分子网络(对此我们已经了解很多)也有助于其在成年生活中的稳态控制(对此我们知之甚少)。重要的是,耳部结构的分子网络已知在苍蝇和人类之间有许多共同之处,我们希望我们的研究将为理解人类听力下降提供一个相关的模型。
项目成果
期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Senses: A Comprehensive Reference
感官:综合参考
- DOI:10.1016/b978-0-12-809324-5.24216-8
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Albert J
- 通讯作者:Albert J
Turnover and activity-dependent transcriptional control of NompC in the Drosophila ear.
- DOI:10.1016/j.isci.2021.102486
- 发表时间:2021-05-21
- 期刊:
- 影响因子:5.8
- 作者:Boyd-Gibbins N;Tardieu CH;Blunskyte M;Kirkwood N;Somers J;Albert JT
- 通讯作者:Albert JT
Turnover and Activity-Dependent Transcriptional Control of NompC (=TRPN1) in the <i>Drosophila</i> Ear
果蝇耳朵中 NompC (=TRPN1) 的周转和活性依赖性转录控制
- DOI:10.2139/ssrn.3611293
- 发表时间:2020
- 期刊:
- 影响因子:0
- 作者:Boyd-Gibbins N
- 通讯作者:Boyd-Gibbins N
A Drosophila model for Meniere's disease: Dystrobrevin is required for support cell function in hearing and proprioception.
- DOI:10.3389/fcell.2022.1015651
- 发表时间:2022
- 期刊:
- 影响因子:5.5
- 作者:
- 通讯作者:
Homeostatic maintenance and age-related functional decline in the Drosophila ear
果蝇耳朵的稳态维持和与年龄相关的功能衰退
- DOI:10.1101/764670
- 发表时间:2019
- 期刊:
- 影响因子:0
- 作者:Keder A
- 通讯作者:Keder A
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Joerg Albert其他文献
Joerg Albert的其他文献
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{{ truncateString('Joerg Albert', 18)}}的其他基金
Acoustic mating in malaria mosquitoes: From signalling logic to vector control
疟疾蚊子的声学交配:从信号逻辑到病媒控制
- 批准号:
BB/V007866/1 - 财政年份:2021
- 资助金额:
$ 91.22万 - 项目类别:
Research Grant
Taiwan Partnering Award: Mosquito Research - From Sensory Biology to Vector Control
台湾合作奖:蚊子研究 - 从感觉生物学到病媒控制
- 批准号:
BB/R021007/1 - 财政年份:2018
- 资助金额:
$ 91.22万 - 项目类别:
Research Grant
The Transcriptomic and Biophysical Basis of Mechanosensory Submodality: A Drosophila Model Organ Study
机械感觉亚模态的转录组学和生物物理基础:果蝇模型器官研究
- 批准号:
BB/L02084X/1 - 财政年份:2014
- 资助金额:
$ 91.22万 - 项目类别:
Research Grant
The role of NompC (=TRPN1) for mechanotransducer gating and adaptation in the Drosophila ear
NompC (=TRPN1) 在果蝇耳朵机械传感器门控和适应中的作用
- 批准号:
BB/G004455/1 - 财政年份:2009
- 资助金额:
$ 91.22万 - 项目类别:
Research Grant
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