SYNTHESIS & MECHANISM--ESPERAMICIN & NEOCARZINOSTATIN

合成

• 批准号: 3195035
• 负责人: PHILIP D MAGNUS
• 金额: $ 14.39万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3195035
• 关键词: chromophore; drug design /synthesis /production; drug metabolism; ketones; neocarzinostatin; neoplasm /cancer pharmacology

The objectives of this research proposal are to examine in a non-convergent manner the synthesis and attendant chemistry of the potent antitumor antibiotics esperamicin A2, calicheamicin, and neocarzinostatin chromophore A, (1, 2 and 3 respectively). The structural factors that influence their proposed biological mode of action will be examined. This involves examining the effect of substituent/structural effects upon the relative rate of 1,4-diyl formation.

本研究计划的目的是在一个非收敛的检验