Synthesis of Diazonamides

描述：（由申请人提供）本研究的长期目标 程序涉及重氮酰胺的合成，和 也可能表现出细胞毒性活性的中间体。所述重氮酰胺是 具有细胞毒性的海洋天然产物，具有前所未有的结构， 其他化合物。据报道，重氮酰胺A具有较强的体外抗肿瘤作用， 对HCT-116人结肠癌和B-16鼠黑素瘤癌的活性 细胞（IC 50小于15 ng/mL）。合成研究的一部分将涉及 产生持久的自由基中间体， 杂环并形成存在于杂环中的关键中心受阻键。 重氮酰胺

DESCRIPTION: (provided by applicant) The long term objectives of this research program are directed towards the synthesis of the diazonamides, and intermediates that may also exhibit cytotoxic activity. The diazonamides are cytotoxic marine natural products that have unprecedented structures unlike any other compounds. It was reported that diazonamide A has potent in vitro activity against HCT-116 human colon carcinoma and B-16 murine melanoma cancer cells (IC50 less than 15 ng/mL). Part of the synthetic studies will involve the generation of persistent radical intermediates that should add to pi-deficient heterocycles and form the key central hindered bond present in the diazonamides.