SYNTHESIS OF DIAZONAMIDES

该研究项目的长期目标是 重氮酰胺的合成以及还可以 表现出细胞毒活性。 重氮酰胺类化合物具有细胞毒性， 天然产物具有前所未有的结构， 化合物. 据报道，重氮酰胺A具有较强的体外抗肿瘤作用， 对HCT-116人结肠癌和B-16鼠黑素瘤的活性 癌细胞（IC 50小于15 ng/mL）。 合成研究的一部分 会产生持久的自由基中间体， 应该添加到π-缺陷杂环，并形成关键的中心 受阻键存在于重氮酰胺中。

The long term objectives of this research program are directed towards the synthesis of the diazonamides, and intermediates that may also exhibit cytotoxic activity. The diazonamides are cytotoxic marine natural products that have unprecedented structures unlike any other compounds. It was reported that diazonamide A has potent in vitro activity against HCT-116 human colon carcinoma and B-16 murine melanoma cancer cells (IC50 is less than 15ng/mL). Part of the synthetic studies will involve the generation of persistent radical intermediates that should add to pi-deficient heterocycles and form the key central hindered bond present in the diazonamides.